FOXR2 Antibody

1. FOXR2 might be considered as a promising therapeutic target for non-small cell lung cancer treatment. PMID: 29634928
2. FOXR2 was up-regulated and significantly associated with poor endometrial adenocarcinoma prognosis. FOXR2 is a target gene of miR-202. PMID: 28827892
3. FOXR2 acts with MYC to promote cancer cell proliferation, which is a potential tumor-specific target for therapeutic intervention against MYC-driven cancers. PMID: 27346356
4. our data suggested that FOXR2 significantly promoted proliferation, invasion, and EMT of CRC cells. All these findings provided evidence for the role of FOXR2 as an oncogene in CRC development. PMID: 28548041
5. Knockdown of FOXR2 significantly down-regulated the protein expression levels of beta-catenin. PMID: 28068638
6. FOXR2 is frequently upregulated in hepatocellular carcinoma specimens compared with neighboring non-cancerous tissues in both messenger RNA and protein. It promoted cell growth and colony formation, and it facilitated tumor xenograft growth. beta-catenin, Skp2, c-Myc, and Gli-1 are the potential downstream effectors of FOXR2. PMID: 26846213
7. we observed that the highly expressed FOXR2 in breast and overexpression of FOXR2 was positively associated with the progression and poor prognosis in patients with breast cancer, which indicated that FOXR2 might serve as a valuable prognosis biomarker for breast cancer individuals. PMID: 26596836
8. Human FOXN6 gene was identified within human genome sequence RP11-167P23 ( PMID: 15202009

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HGNC: 30469

OMIM: 300949

KEGG: hsa:139628

STRING: 9606.ENSP00000427329

UniGene: Hs.364260