GOPC Antibody

1. PIST, a Golgi-associated PDZ domain-containing protein, interacts with PCDH15 in the plasma membrane. PMID: 27867666
2. CAL can regulate the anterograde trafficking, the internalization as well as the signaling of CRFR1 via modulating the post-translational modifications that the receptor undergoes at the Golgi apparatus. PMID: 26115868
3. CAL overexpression retards B2AR expression in Golgi apparatus and reduces the receptor expression in the plasma membrane. PMID: 25876703
4. Six out of 65 (9%) BTC patients were positive for the FIG-ROS1 fusion, comprising two out of 14 (14%) gallbladder carcinoma (GBC) patients and four out of 25 (16%) extrahepatic cholangiocarcinoma (ECC) patients. PMID: 25231053
5. Our data suggest that PIST contributes to the fine-tuning of b1AR sorting both during biosynthetic and postendocytic trafficking PMID: 25614626
6. None of 268 gliomas analysed showed the FIG-ROS1(L) rearrangement. PMID: 24999209
7. Stereochemical preferences modulate affinity and selectivity among CAL PDZ domain protein variants that bind CFTR. PMID: 24210758
8. FIG-ROS fusion protein, which is found in a subset of intrahepatic cholangiocarcinoma patients, accelerates cholangiocarcinogenesis. PMID: 24154728
9. Data indicate that E3 ubiquitin ligase MARCH2 co-immunoprecipitated and co-localized with CAL and syntaxin 6 (STX6), and show the ubiquitination of CFTR by MARCH2. PMID: 23818989
10. The coiled-coil domain of PIST was then purified to homogeneity and crystallized at 293 K. Finally, X-ray diffraction data were collected to a resolution of 4.0 A from a crystal belonging to the hexagonal space group P6(2)22 or P6(4)22. PMID: 23545662
11. crystals of CAL PDZ domain diffracted to 1.4 A resolution PMID: 21543871
12. establish CAL inhibitors as founding members of a class of CFTR "stabilizers" specifically designed to reduce DeltaF508-CFTR post-endocytic breakdown PMID: 21105033
13. Syntaxin 6 and CAL mediate the degradation of the cystic fibrosis transmembrane conductance regulator PMID: 20130090
14. The FIG-ROS locus encodes for an in-frame fusion protein with a constitutively active kinase activity, suggesting that FIG-ROS may act as an oncogene. PMID: 12661006
15. CAL retains CFTR in the cell and targets CFTR for degradation. PMID: 14570915
16. modulates beta1AR intracellular trafficking PMID: 15358775
17. golgin-160 assosiates in an isoform-specific manner with the Golgi-associated protein PIST PMID: 15951434
18. intracellular sorting of the somatostatin receptor subtype 5 is regulated by interactions with PDZ domain proteins PIST/GOPC and PDZK1 PMID: 16012170
19. Our discoveries provide insight into the specific interaction of the GOPC PDZ domain with the C-terminal peptide of Nlg and also provide a general insight about the possible binding mode of the interaction of Nlg with other PDZ domain-containing proteins. PMID: 16882988
20. CAL is a negative regulator of DeltaF508-CFTR cell-surface expression PMID: 17158866
21. The cystic fibrosis-associated ligand (CAL) PDZ domain of the C-terminus of cystic fibrosis-associated conductance regulator (CFTR) is competitively involved with PDZ proteins Na+/H+ exchanger-3 regulatory factors NHERF1 and NHERF2. PMID: 18754678

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HGNC: 17643

OMIM: 606845

KEGG: hsa:57120

STRING: 9606.ENSP00000357484

UniGene: Hs.191539