LILRA4 Antibody

Code CSB-PA012936LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA012936LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA012936LA01HU at dilution of 1:100

  • Immunofluorescent analysis of HepG2 cells using CSB-PA012936LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) LILRA4 Polyclonal antibody
Uniprot No.
Target Names
LILRA4
Alternative Names
LILRA4; ILT7; Leukocyte immunoglobulin-like receptor subfamily A member 4; CD85 antigen-like family member G; Immunoglobulin-like transcript 7; ILT-7; CD antigen CD85g
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Leukocyte immunoglobulin-like receptor subfamily A member 4 protein (289-424AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The LILRA4 Antibody (Product code: CSB-PA012936LA01HU) is Non-conjugated. For LILRA4 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA012936LB01HU LILRA4 Antibody, HRP conjugated ELISA
FITC CSB-PA012936LC01HU LILRA4 Antibody, FITC conjugated
Biotin CSB-PA012936LD01HU LILRA4 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
Gene References into Functions
  1. Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC. PMID: 24586760
  2. ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs. PMID: 23401591
  3. Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested. PMID: 22674796
  4. the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells PMID: 12384430
  5. ILT7 protein associates with the signal adapter protein Fc epsilonRI gamma to form a receptor complex in dendritic cells. PMID: 16735691
  6. key regulator of human pDC function and interferon type I production. PMID: 18048391
  7. Data show that BST2 directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7/9 responses in plasmacytoid dendritic cells. PMID: 19564354

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Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.
Database Links

HGNC: 15503

OMIM: 607517

KEGG: hsa:23547

STRING: 9606.ENSP00000291759

UniGene: Hs.406708

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