LILRA4 Recombinant Monoclonal Antibody

Datasheet

Code	CSB-RA012936MA1HU
Size	US$210
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Image	Western Blot Positive WB detected in:Hela whole cell lysate (20µg), HpeG2 whole cell lysate (20µg), Jurkat whole cell lysate (20µg), K562 whole cell lysate (20µg) All lanes: LILRA4 antibody at 1:1000 Secondary Goat polyclonal to human IgG at 1/40000 dilution Predicted band size:55.18, 47.81 kDa Observed band size:50 kDa Exposure time:20s IHC image of CSB-RA012936MA1HU diluted at 1:100 and staining in paraffin-embedded human skin tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
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Product Details
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Target Background

Product Details

Uniprot No.

P59901

Target Names

LILRA4

Alternative Names

CD85 antigen-like family member G antibody; CD85g antibody; ILT-7 antibody; ILT7 antibody; Immunoglobulin like transcript 7 antibody; Immunoglobulin-like transcript 7 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 4 antibody; LILRA4 antibody; LIRA4_HUMAN antibody; MGC129597 antibody; MGC129598 antibody

Species Reactivity

Human

Immunogen

Recombinant Human LILRA4 protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Monoclonal

Isotype

hIgG1

Clone No.

24F6

Purification Method

Affinity-chromatography

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:50-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.

Gene References into Functions

Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC. PMID: 24586760
ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs. PMID: 23401591
Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested. PMID: 22674796
the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells PMID: 12384430
ILT7 protein associates with the signal adapter protein Fc epsilonRI gamma to form a receptor complex in dendritic cells. PMID: 16735691
key regulator of human pDC function and interferon type I production. PMID: 18048391
Data show that BST2 directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7/9 responses in plasmacytoid dendritic cells. PMID: 19564354

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.

Database Links

HGNC: 15503

OMIM: 607517

KEGG: hsa:23547

STRING: 9606.ENSP00000291759

UniGene: Hs.406708

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Service

Phage Display Service

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Protein Service

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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