LZTFL1 Antibody

Datasheet

Code	CSB-PA885687LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: HEK293 whole cell lysate, HepG2 whole cell lysate, Hela whole cell lysate, U251 whole cell lysate All lanes: LZTFL1 antibody at 3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 35, 33, 30 kDa Observed band size: 35, 50 kDa Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA885687LA01HU at dilution of 1:100 Immunofluorescent analysis of U251 cells using CSB-PA885687LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) Immunoprecipitating LZTFL1 in HepG2 whole cell lysate Lane 1: Rabbit control IgG instead of (1µg) instead of CSB-PA885687LA01HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated light chain specific antibody was used as the Secondary antibody (1/50000) Lane 2: CSB-PA885687LA01HU (4µg) + HepG2 whole cell lysate (500µg) Lane 3: HepG2 whole cell lysate (20µg)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) LZTFL1 Polyclonal antibody

Uniprot No.

Q9NQ48

Target Names

LZTFL1

Alternative Names

5530402H04Rik antibody; 6130400H19Rik antibody; AI414725 antibody; AW048545 antibody; BBS17 antibody; DKFZp686H2076 antibody; FLJ36386 antibody; Leucine zipper transcription factor like 1 antibody; Leucine zipper transcription factor like protein 1 antibody; Leucine zipper transcription factor-like protein 1 antibody; LZTFL 1 antibody; Lztfl1 antibody; Lztfl1 leucine zipper transcription factor-like 1 antibody; LZTL1_HUMAN antibody; MGC106871 antibody; MGC108960 antibody; Putative uncharacterized protein DKFZp686H2076 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Leucine zipper transcription factor-like protein 1 protein (116-299AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The LZTFL1 Antibody (Product code: CSB-PA885687LA01HU) is Non-conjugated. For LZTFL1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA885687LB01HU	LZTFL1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA885687LC01HU	LZTFL1 Antibody, FITC conjugated
Biotin	CSB-PA885687LD01HU	LZTFL1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC, IF, IP

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200
IP	1:200-1:2000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Immunoprecipitation (IP) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.

Gene References into Functions

LZTFL1 inhibits lung tumorigenesis PMID: 26364604
these data indicate that LZTFL1 modulates T cell activation and IL-5 levels. PMID: 26700766
LZTFL1 binds beta-catenin in the cytoplasm of the cell and inhibited its nuclear translocation PMID: 25005785
This special subtype of polydactyly in BBS patients is easily identified on clinical examination and prompts for priority sequencing of LZTFL1 (BBS17). PMID: 23692385
The absence of LZTFL1 leads to a BBS phenotype with enhanced developmental abnormalities associated with cellular Shh dysfunction. LZTFL1 is a novel BBS gene (BBS17). PMID: 22510444
Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling PMID: 22072986
LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation. PMID: 20233871

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Involvement in disease

Bardet-Biedl syndrome 17 (BBS17)

Subcellular Location

Cytoplasm.

Protein Families

LZTFL1 family

Tissue Specificity

Expressed in prostate, ovary, stomach, pancreas, esophagus, breast, liver, bladder, kidney, thyroid, colon and lung (at protein level). Down-regulated in multiple primary tumors (at protein level). Detected in testis, heart, skeletal muscle, thymus, splee

Database Links

HGNC: 6741

OMIM: 606568

KEGG: hsa:54585

STRING: 9606.ENSP00000296135

UniGene: Hs.30824

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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