MADD Antibody

1. The risk of coronary disease and ischemic stroke associated with multiple polymorphisms and haplotypes of MADD and FOLH1 in Han Chinese patients are reported in association with alcohol consumption. PMID: 27070640
2. miR-3151 silencing by DNA methylation protected chronic lymphocytic leukemia cells from apoptosis by over-expression of its direct targets MADD and PIK3R2, constitutive activation of MEK/ERK and PI3K/AKT signaling , and over-expression of MCL1. PMID: 26517243
3. Taken together, our data reveal that PTEN can convey the death signal by preventing MADD phosphorylation by Akt. PMID: 24038283
4. These results suggest that MADD may be a potential therapeutic target for lung adenocarcinoma therapy involving the TRAIL-induced apoptosis pathway PMID: 23443411
5. MADD knockdown resulted in enhanced spontaneous apoptosis in human breast cancer cell lines PMID: 23457619
6. We analyzed DENN/MADD/IG20 (DMI), the complex of four splice variants in Alzheimer's disease. PMID: 22678883
7. SNP rs2290149, located in a genetic cluster of MYBPC3 and MADD gene, was found to be associated with diastolic heart failure. PMID: 22529996
8. Data show that ehe expression of MAPK-activating death domain protein (MADD) increases obviously in lung adenocarcinoma, and MADD can promote survival of lung adenocarcinoma cells by inhibiting apoptosis. PMID: 22482404
9. The SNP in ADCY5 is implicated in defective proinsulin-to-insulin conversion and previous findings on the role of a genetic variant in MADD on proinsulin-to-insulin conversion, were confirmed. PMID: 21887289
10. Data show that SNPs from MADD, PROX1, and SLC30A8 were associated with type 2 diabetes. PMID: 21103350
11. Endogenous MADD is phosphorylated at three highly conserved sites by Akt, and only the phosphorylated MADD can directly interact with the TRAIL receptor DR4 thereby preventing Fas-associated death domain recruitment. PMID: 20484047
12. Denn is intimately involved in anti-apoptotic and cell survival processes in cancer cells PMID: 12410563
13. IG20 overexpression enhanced the combined apoptotic effects of TRAIL and gamma-irradiation on HeLa cells. PMID: 14695193
14. IG20 suppresses tumor cell survival and enhances susceptibility to apoptosis and cancer therapy. PMID: 14716293
15. DENN has anti-apoptotic and cell survival roles in tumor cells PMID: 14735464
16. IG20 (MADD splice variant-5) enhances TRAIL-induced apoptosis by increasing recruitment of FADD and caspase-8 to the death-inducing signaling complex. PMID: 15208670
17. Knockdown of MADD can render cells susceptible to spontaneous apoptosis but had no discernible effect on cell proliferation, colony size or cell cycle progression. MADD alone is sufficient and necessary for cancer cell survival. PMID: 16682944
18. MADD has a role in the control of cancer cell survival/death as a negative regulator of caspase-8 and confers significant resistance to TRAIL-induced apoptosis PMID: 17314102
19. data strongly indicate that germline mutations in SPI1 and MADD genes do not confer a high risk of chronic lymphocytic leukaemia and do not make a major contribution to the familial risk of the disease PMID: 17410194
20. we have identified an essential role for splice variants of the IG20 gene in TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)resistance. PMID: 18223207
21. Expression of KIAA0358 exerted a potent antiapoptotic effect in both the SK-N-SH and SH-SY5Y neuroblastoma cell lines, whereas expression of IG20-SV4 had proapoptotic effects directly related to the activation of caspase-8 in these cells. PMID: 18794122
22. KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through MADD. PMID: 18849981
23. Loss of MADD expression resulted in reduced Grb2 and Sos1/2 recruitment to the TNFR1 complex and decreased Ras and MEKK1/2 activation PMID: 19289468

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HGNC: 6766

OMIM: 603584

KEGG: hsa:8567

STRING: 9606.ENSP00000310933

UniGene: Hs.82548