MARCKSL1 Antibody

Code CSB-PA013494DSR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA013494DSR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA013494DSR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MARCKSL1 Polyclonal antibody
Uniprot No.
Target Names
MARCKSL1
Alternative Names
F52 antibody; Mac MARCKS antibody; Mac-MARCKS antibody; MacMARCKS antibody; Macrophage enriched Myristoylated Alanine Rich C Kinase Substrate Like Protein antibody; Macrophage myristoylated alanine-rich C kinase substrate antibody; MARCKS like 1 antibody; MARCKS like protein 1 antibody; MARCKS related protein antibody; MARCKS-like protein 1 antibody; MARCKS-related protein antibody; MARCKSL1 antibody; MLP antibody; MLP1 antibody; MRP antibody; MRP_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human MARCKS-related protein (1-195AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Gene References into Functions
  1. MARCKSL1 showed potent anti-angiogenic activity and reduced the levels of VEGF and HIF-1alpha expression. MARCKSL1 decreased VEGFinduced phosphorylation of the PI3K/Akt signaling pathway components. PMID: 26555156
  2. MARCKSL1 suppresses LOXL2-induced oncogenesis. PMID: 24863880
  3. Patients with high expression of PPH3 and high MARCKSL1 protein had a lower survival rate versus patients with low MARCKSL1 and high PPH3 expression. PMID: 22772381
  4. Gene knockdown in prostate cancer cells or in neurons reveals a critical role for MARCKSL1 in migration that is dependent on the phosphorylation state. PMID: 22751924
Subcellular Location
Cytoplasm, cytoskeleton. Cell membrane; Lipid-anchor.
Protein Families
MARCKS family
Database Links

HGNC: 7142

OMIM: 602940

KEGG: hsa:65108

STRING: 9606.ENSP00000362638

UniGene: Hs.75061

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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