F52 antibody; Mac MARCKS antibody; Mac-MARCKS antibody; MacMARCKS antibody; Macrophage enriched Myristoylated Alanine Rich C Kinase Substrate Like Protein antibody; Macrophage myristoylated alanine-rich C kinase substrate antibody; MARCKS like 1 antibody; MARCKS like protein 1 antibody; MARCKS related protein antibody; MARCKS-like protein 1 antibody; MARCKS-related protein antibody; MARCKSL1 antibody; MLP antibody; MLP1 antibody; MRP antibody; MRP_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Human Marcksl1
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems.
Gene References into Functions
MARCKSL1 showed potent anti-angiogenic activity and reduced the levels of VEGF and HIF-1alpha expression. MARCKSL1 decreased VEGFinduced phosphorylation of the PI3K/Akt signaling pathway components. PMID: 26555156
Patients with high expression of PPH3 and high MARCKSL1 protein had a lower survival rate versus patients with low MARCKSL1 and high PPH3 expression. PMID: 22772381
Gene knockdown in prostate cancer cells or in neurons reveals a critical role for MARCKSL1 in migration that is dependent on the phosphorylation state. PMID: 22751924