METRNL Antibody

Code CSB-PA731035LA01HU
Size US$166
Order now
Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, U87 whole cell lysate, K562 whole cell lysate, PC3 whole cell lysate, Mouse brain tissue, Rat kidney tissue, Rat brain tissue
    All lanes: METRNL antibody at 1:2000
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 35, 26 KDa
    Observed band size: 35 KDa
    Exposure time:1min
The Latest Promotion Free Antibody trial simple
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) METRNL Polyclonal antibody
Uniprot No.
Target Names
METRNL
Alternative Names
Meteorin like glial cell differentiation regulator antibody; Meteorin; glial cell differentiation regulator like antibody; Meteorin-like protein antibody; METRL_HUMAN antibody; Metrnl antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant Human Meteorin-like protein
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The METRNL Antibody (Product code: CSB-PA731035LA01HU) is Non-conjugated. For METRNL Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA731035LB01HU METRNL Antibody, HRP conjugated ELISA
FITC CSB-PA731035LC01HU METRNL Antibody, FITC conjugated
Biotin CSB-PA731035LD01HU METRNL Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form
Liquid
Tested Applications
ELISA, WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The METRNL antibody was raised in rabbits using the recombinant human METRNL protein as the immunogen. It underwent antigen affinity purification. This rabbit anti-human METRNL polyclonal antibody exhibits high specificity for METRNL protein from human, mouse, and rat samples. The target protein METRNL is a novel adipokine that has been shown to play a role in metabolic regulation, insulin sensitivity, and energy homeostasis.

This antibody can be used in ELISA and WB applications. And it may be useful in metabolic disorders and related fields.

Customer Reviews and Q&A

 Customer Reviews
Average Rating:
5.0 - 2 reviews

Submit a Review here

Applications : Western Blot (WB)

Sample type: cell

Review: I used CSB-PA731035LA01HU antibody, WB) assay, detection of mouse liver tissue samples, sample processing situation is 60hz grinder grinding for five minutes, its results are attached, clear bands without spurious bands, good specificity.

By Anonymous

Applications : Western Blot (WB)

Sample type: Skeletal tissue and skeletal muscle primary cells, rat

Sample dilution: 1:5000

Review: Using CSB-PA731035LA01HU Antibody, WB detection, detection of rat skeletal muscle tissue and skeletal muscle progenitor cells at a dilution ratio of 1:5000, the results are shown in the attached figure, which shows that the bands are clear and free of heterogeneous bands, with the correct location and good specificity.

By Anonymous

Target Background

Function
Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures.
Gene References into Functions
  1. downregulation of METRNL during adipogenesis and functional induction of increased proliferation in stromal vascular fraction cells with concomitant inhibition of adipocyte differentiation may result in hypertrophic AT accumulation PMID: 27748745
  2. Overexpression of METRNL inhibited mineralized nodule formation. PMID: 27716826
  3. Data suggest that there is no correlation between serum Metrnl levels and BMI (body mass index) in humans. PMID: 26307585
  4. Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin PMID: 24393292
Subcellular Location
Secreted.
Protein Families
Meteorin family
Tissue Specificity
Highly expressed in the skeletal muscle, in subcutaneous adipose tissue, epididymal white adipose tissue depots and heart. Also expressed in brown adipose tissues and kidney.
Database Links

HGNC: 27584

OMIM: 616241

KEGG: hsa:284207

STRING: 9606.ENSP00000315731

UniGene: Hs.378821

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*