MICU2 Antibody

1. MICU2 restricts spatial crosstalk between InsP3R and MCU channels by regulating threshold and gain of MICU1-mediated inhibition and activation of MCU. PMID: 29241542
2. MICU2 expression in the heart tissues from patients with ventricular hypertrophy. PMID: 29073106
3. study concludes that cooperative, high-affinity interaction of the MICU1-MICU2 complex with Ca(2+) serves as an on-off switch, leading to a tightly controlled channel, capable of responding directly to cytosolic Ca(2+) signals PMID: 28615291
4. This is the first demonstration of MICU2 deficiency in humans, which we suggest causes a distinct neurodevelopmental phenotype secondary to impaired mitochondrial calcium uniporter-mediated regulation of intracellular calcium homeostasis. PMID: 29053821
5. Expression of MICU2 mutants lacking functional Ca2+-binding sites leads to a striking loss of Ca2+ uptake in HEK293 cells. PMID: 24503055
6. MICU1 and MICU2 have roles in tuning the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity PMID: 24560927
7. The results identify MICU2 as a new component of the uniporter complex that may contribute to the tissue-specific regulation of this channel. PMID: 23409044
8. regulation of MCU-mediated mitochondrial calcium handling PMID: 23409044
9. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
10. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614

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HGNC: 31830

OMIM: 610632

KEGG: hsa:221154

STRING: 9606.ENSP00000371811

UniGene: Hs.412103