MID2 Antibody

Code CSB-PA892324ESR1HU
Size US$166
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Image
  • Western blot
    All lanes: MID2 antibody at 3.32 μg/ml + Mouse small intestine tissue
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 84, 80 kDa
    Observed band size: 84, 30 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA892324ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA892324ESR1HU at dilution of 1:100

  • Immunofluorescent analysis of MCF-7 cells using CSB-PA892324ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) MID2 Polyclonal antibody
Uniprot No.
Target Names
MID2
Alternative Names
FLJ37715 antibody; FLJ41813 antibody; FXY2 antibody; MID2 antibody; Midin 2 antibody; Midin-2 antibody; Midline 2 antibody; Midline defect 2 antibody; Midline-2 antibody; probable E3 ubiquitin protein ligase MID2 antibody; Probable E3 ubiquitin-protein ligase MID2 antibody; RING finger protein 60 antibody; Ring finger protein protein 60 antibody; RNF60 antibody; TRIM1 antibody; TRIM1_HUMAN antibody; tripartite motif containing protein 1 antibody; Tripartite motif protein 1 antibody; Tripartite motif-containing protein 1 antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Probable E3 ubiquitin-protein ligase MID2 protein (506-735AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May play a role in microtubule stabilization.
Gene References into Functions
  1. overexpressed in advanced breast cancer and high overexpression is prognostic factor for poor overall survival PMID: 26791755
  2. Mid2 regulates cell division through the ubiquitination of astrin on K409, which is critical for its degradation and proper cytokinesis. PMID: 26748699
  3. A novel missense mutation (c.1040G>A, p.Arg347Gln) was reported in MID2, which encodes ubiquitin ligase E3, as the likely cause of X-linked mental retardation in a large kindred. PMID: 24115387
  4. MID2 coiled-coil motifs mediate both homo- and heterodimerization, a prerequisite for association of the MID-alpha 4 complex with microtubules. PMID: 11806752
  5. MID2 is a candidate gene for FG syndrome. PMID: 16283679

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Involvement in disease
Mental retardation, X-linked 101 (MRX101)
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated.
Protein Families
TRIM/RBCC family
Tissue Specificity
Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine.
Database Links

HGNC: 7096

OMIM: 300204

KEGG: hsa:11043

STRING: 9606.ENSP00000262843

UniGene: Hs.12256

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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