PLEKHA8 Antibody

Datasheet

Code	CSB-PA856957LA01HU
Size	US$166
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Image	Western blot All lanes: PLEKHA8 antibody at 0.8μg/ml + Mouse brain tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 59, 52, 50 kDa Observed band size: 59 kDa Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA856957LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA856957LA01HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PLEKHA8 Polyclonal antibody

Uniprot No.

Q96JA3

Target Names

PLEKHA8

Alternative Names

FAPP-2 antibody; FAPP2 antibody; hFAPP2 antibody; MGC3358 antibody; PH domain-containing family A member 8 antibody; Phosphatidylinositol-four-phosphate adapter protein 2 antibody; Phosphoinositide binding specificmember 8 antibody; Phosphoinositol 4 phosphate adaptor protein 2 antibody; Phosphoinositol 4-phosphate adapter protein 2 antibody; PKHA8_HUMAN antibody; Pleckstrin homology domain containing A8 antibody; Pleckstrin homology domain containing family A (Phosphoinositide binding specific) member 8 antibody; Pleckstrin homology domain containing family A antibody; Pleckstrin homology domain-containing family A member 8 antibody; Plekha8 antibody; PLEKHA8 protein antibody; Serologically defined breast cancer antigen NY-BR-86 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Pleckstrin homology domain-containing family A member 8 protein (1-300AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PLEKHA8 Antibody (Product code: CSB-PA856957LA01HU) is Non-conjugated. For PLEKHA8 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA856957LB01HU	PLEKHA8 Antibody, HRP conjugated	ELISA
FITC	CSB-PA856957LC01HU	PLEKHA8 Antibody, FITC conjugated
Biotin	CSB-PA856957LD01HU	PLEKHA8 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

Gene References into Functions

Altogether, this study implies that hepatitis C virus coopts FAPP2 for virus genome replication via phosphatidylinositol 4-phosphate binding and glycosphingolipid transport to the hepatitis C virus replication complex. PMID: 25122779
FAPP2 functions in both membrane trafficking and lipid metabolism in a fashion that integrates its activities in membrane trafficking and in lipid transfer. (Review) PMID: 22266015
Data demonstrate FAPP2 is required for cilium formation in polarized MDCK cells. PMID: 17116893
Data show that FAPP2 is present in tubules forming from the trans-Golgi in epithelial MDCK cells. PMID: 19940249
FAPP2 plays a specific role in apical transport in MDCK cells. PMID: 16103222
by coupling the synthesis of glycosphingolipids with their export to the cell surface, FAPP2 emerges as crucial in determining the lipid identity and composition of the plasma membrane PMID: 17687330
These data demonstrate a previously unknown role for FAPP2 in conferring resistance to apoptosis and indicate that FAPP2 may be a target for cancer therapy. PMID: 19341712

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Subcellular Location

Golgi apparatus, trans-Golgi network membrane. Membrane; Peripheral membrane protein.

Tissue Specificity

Expressed in kidney cell lines.

Database Links

HGNC: 30037

OMIM: 608639

KEGG: hsa:84725

STRING: 9606.ENSP00000397947

UniGene: Hs.233495

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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