PPP1R3B Antibody

Datasheet

Code	CSB-PA769802LA01HU
Size	US$166
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Image	Western blot All lanes: PPP1R3B antibody at 6µg/ml + Mouse liver tissue Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 33 kDa Observed band size: 33 kDa Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA769802LA01HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA769802LA01HU at dilution of 1:100 Western Blot Positive WB detected in: Rat heart tissue All lanes: PPP1R3B antibody at 2.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 33 kDa Observed band size: 33 kDa
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PPP1R3B Polyclonal antibody

Uniprot No.

Q86XI6

Target Names

PPP1R3B

Alternative Names

FLJ14005 antibody; FLJ34675 antibody; GL antibody; Hepatic glycogen targeting protein phosphatase 1 regulatory subunit GL antibody; Hepatic glycogen targeting subunit G(L) antibody; Hepatic glycogen-targeting protein phosphatase 1 regulatory subunit GL antibody; PP1 subunit R4 antibody; Ppp1r3b antibody; PPP1R4 antibody; PPR3B_HUMAN antibody; Protein phosphatase 1 regulatory (inhibitor) subunit 3B antibody; Protein phosphatase 1 regulatory subunit 3B antibody; Protein phosphatase 1 regulatory subunit 4 antibody; Protein phosphatase 1 subunit 4 antibody; Protein phosphatase 1 subunit GL antibody; PTG antibody; R4 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Protein phosphatase 1 regulatory subunit 3B protein (1-285AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PPP1R3B Antibody (Product code: CSB-PA769802LA01HU) is Non-conjugated. For PPP1R3B Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA769802LB01HU	PPP1R3B Antibody, HRP conjugated	ELISA
FITC	CSB-PA769802LC01HU	PPP1R3B Antibody, FITC conjugated
Biotin	CSB-PA769802LD01HU	PPP1R3B Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The PPP1R3B polyclonal antibody is produced in rabbits using recombinant human protein phosphatase 1 regulatory subunit 3B protein (1-285aa) as an immunogen. Protein G affinity chromatography was used to purify the antibody, achieving a purity level exceeding 95%, ensuring high quality and freedom from impurities that may interfere with experimental results.

This PPP1R3B antibody is capable of detecting PPP1R3B protein in human, mouse, and rat samples. It has been extensively tested in various applications, including ELISA, WB, and IHC, for the qualitative and quantitative detection of PPP1R3B protein, as well as the determination of the presence and size and detection of localization and expression levels of this protein.

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Target Background

Function

Acts as a glycogen-targeting subunit for phosphatase PP1. Facilitates interaction of the PP1 with enzymes of the glycogen metabolism and regulates its activity. Suppresses the rate at which PP1 dephosphorylates (inactivates) glycogen phosphorylase and enhances the rate at which it activates glycogen synthase and therefore limits glycogen breakdown. Its activity is inhibited by PYGL, resulting in inhibition of the glycogen synthase and glycogen phosphorylase phosphatase activities of PP1. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in hepatocytes.

Gene References into Functions

These observations are consistent with the notion that the minor allele of rs4841132 promotes a mild form of hepatic glycogenosis that is associated with hepatic injury PMID: 29266543
rs9987289 A-allele was associated with plasma lactate in European-Americans but not in African-Americans. PMID: 26433129
Among Mexicans, the PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), and GCKR (rs780094) polymorphisms may be associated with a greater risk of chronic liver disease among overweight adults. PMID: 27752939
A novel role for PTG in protecting hepatocellular carcinoma cells from metabolic stress, in part by regulating oxidative stress and autophagy. PMID: 26182369
Some, but not all, associations between variants in NCAN, lysophospholipase-like 1, GCKR, and PPP1R3B with hepatic steatosis (with and without increased ALT level) were significant within subpopulations. PMID: 23416328
Data indicate that genetic polymorphisms of the PPP1R3B gene may contribute to variations in plasma lipids and C-reactive protein (CRP) levels among Chinese Han individuals. PMID: 23343124
Results suggest that in cultured human myotubes, glycogen-targeting PP1 (protein phosphatase 1) subunit G(L) (coded for by the PPP1R3B gene) is expressed as in muscle tissue and is unresponsive to glucose or insulin, as are G(M) and PTG genes. PMID: 17555403

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Tissue Specificity

Highly expressed in the liver and, at lower levels, in skeletal muscle, including in vastus lateralis, gastrocnemius and soleus (at protein level). Highest mRNA levels are observed in skeletal muscle, and only moderate levels in liver and heart. Weak expr

Database Links

HGNC: 14942

OMIM: 610541

KEGG: hsa:79660

STRING: 9606.ENSP00000308318

UniGene: Hs.458513

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Related pathways

Insulin signaling pathway

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