STK33 Antibody

Code CSB-PA861179LA01HU
Size US$166
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Image
  • Western blot
    All lanes: STK33 antibody at 4µg/ml
    Lane 1: Mouse kidney tissue
    Lane 2: Hela whole cell lysate
    Lane 3: Jurkat whole cell lysate
    Secondary
    Goat polyclonal to rabbit IgG at 1/10000 dilution
    Predicted band size: 58, 51 kDa
    Observed band size: 58 kDa

  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA861179LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA861179LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) STK33 Polyclonal antibody
Uniprot No.
Target Names
STK33
Alternative Names
Hypothetical protein FLJ35932 antibody; Serine threonine kinase 33 antibody; Serine/threonine kinase 33 antibody; Serine/threonine protein kinase 33 antibody; Serine/threonine-protein kinase 33 antibody; STK 33 antibody; Stk33 antibody; STK33_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Recombinant Human Serine/threonine-protein kinase 33 protein (231-514AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The STK33 Antibody (Product code: CSB-PA861179LA01HU) is Non-conjugated. For STK33 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA861179LB01HU STK33 Antibody, HRP conjugated ELISA
FITC CSB-PA861179LC01HU STK33 Antibody, FITC conjugated
Biotin CSB-PA861179LD01HU STK33 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Serine/threonine protein kinase which phosphorylates VIME. May play a specific role in the dynamic behavior of the intermediate filament cytoskeleton by phosphorylation of VIME. Not essential for the survival of KRAS-dependent AML cell lines.
Gene References into Functions
  1. Dysregulated HIF1alpha/STK33 signaling promotes pancreatic ductal adenocarcinoma (PDAC) growth and progression, this suggests that STK33 is a candidate therapeutic target to improve PDAC treatment. PMID: 29038348
  2. STK33 is a potential oncogene and plays an important role in tumorigenesis of HSCC via regulation of numerous genes. PMID: 27414193
  3. STK33 plays an essential role in hepatocellular proliferation and liver tumorigenesis. STK33 may bind directly to c-Myc and increase its transcriptional activity. PMID: 25398772
  4. Results show that STK33 is a potential oncogene and a promising diagnostic marker for hypopharyngeal squamous cell carcinoma (HSCC). STK33 may promote tumorigenesis and progression of HSCC, and serve as a valuable molecular target for treatment of HSCC. PMID: 25603720
  5. STK33 can promote cell migration and invasion and suppress p53 gene expression in the NL9980 and L9981 large cell lung cancer cell lines. In addition, this protein also promotes epithelial-mesenchymal transition. PMID: 25662617
  6. The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children. PMID: 23967198
  7. STK33 downregulation or dominant mutant overexpression had no effect on KRAS signaling or survival of cancer cells. PMID: 21742770
  8. STK33/Stk33 expression pattern resembles those of some related members of the calcium/calmodulin dependent kinase group PMID: 16176263

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Subcellular Location
Cytoplasm, perinuclear region.
Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, CaMK subfamily
Tissue Specificity
Highly expressed in testis, fetal lung and heart, followed by pituitary gland, kidney, interventricular septum, pancreas, heart, trachea, thyroid gland and uterus. Weak hybridization signals were observed in the following tissues: amygdala, aorta, esophag
Database Links

HGNC: 14568

OMIM: 607670

KEGG: hsa:65975

STRING: 9606.ENSP00000320754

UniGene: Hs.501833

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