TSPEAR Antibody

Datasheet

Code	CSB-PA848817LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Raji whole cell lysate All lanes: TSPEAR antibody at 3.5µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 75, 67 kDa Observed band size: 75 kDa
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) TSPEAR Polyclonal antibody

Uniprot No.

Q8WU66

Target Names

TSPEAR

Alternative Names

Thrombospondin-type laminin G domain and EAR repeat-containing protein antibody; TSEAR_HUMAN antibody; TSP-EAR antibody; TSPEAR antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Thrombospondin-type laminin G domain and EAR repeat-containing protein (248-433AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The TSPEAR Antibody (Product code: CSB-PA848817LA01HU) is Non-conjugated. For TSPEAR Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA848817LB01HU	TSPEAR Antibody, HRP conjugated	ELISA
FITC	CSB-PA848817LC01HU	TSPEAR Antibody, FITC conjugated
Biotin	CSB-PA848817LD01HU	TSPEAR Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Plays a critical role in tooth and hair follicle morphogenesis through regulation of the Notch signaling pathway. May play a role in development or function of the auditory system.

Gene References into Functions

TSPEAR mutation is associated with tooth agenesis. PMID: 30046887
using a luciferase-based reporter assay, we showed that TSPEAR knock-down is associated with decreased Notch signaling. In addition, NOTCH1 protein expression was reduced in patient scalp skin. Moreover, TSPEAR silencing in mouse hair follicle organ cultures was found to induce apoptosis in follicular epithelial cells, resulting in decreased hair bulb diameter PMID: 27736875
TSPEAR expression is significantly downregulated in human masticatory mucosa during wound healing PMID: 28005267
TSPEAR, cause disorders with auditory features: epilepsy, which can include auditory features in humans; audiogenic seizures in animals; and/or hearing impairments in humans and mice. PMID: 22678063
The TSPEAR/C21orf29 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980

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Involvement in disease

Deafness, autosomal recessive, 98 (DFNB98)

Subcellular Location

Secreted. Cell surface. Cell projection, stereocilium.

Database Links

HGNC: 1268

OMIM: 612920

KEGG: hsa:54084

STRING: 9606.ENSP00000321987

UniGene: Hs.660703

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Service

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Protein Service

Gene Synthesis Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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