WDHD1 Antibody

1. And-1 interacts with CtIP and that these interactions are required for DNA damage checkpoint maintenance, thereby linking DNA processing with prolonged cell cycle arrest to allow sufficient time for DNA repair. PMID: 27940552
2. important role of And-1 in homologous recombination repair by regulating CtIP-mediated DNA double-strand break end resection PMID: 27940557
3. findings provide important insights into the mechanistic details of human AND-1 function, advancing our understanding of replisome formation during eukaryotic replication. PMID: 28381552
4. The WDHD1 gene, one of the genes that is upregulated in human papillomavirus E7-expressing cells, was found to play an important role in E7-induced G1 checkpoint abrogation and rereplication PMID: 27099318
5. Results provide additional evidence suggesting that WDHD1 is involved in the mismatch repair pathway. PMID: 27037360
6. RecQL4-dependent association of Mcm10 and Ctf4 with replication origins appears to be the first important step controlled by S phase promoting kinases and checkpoint pathways for the initiation of DNA replication in human cells. PMID: 25602958
7. And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress. PMID: 26082189
8. The Ctf4-CMG complex contains a homodimeric Ctf4 that acts as a platform linking polymerase alpha to the monomeric hCMG complex. PMID: 24255107
9. And-1 together with HJURP regulates the assembly of new CENP-A onto centromeres. PMID: 23184928
10. Human And-1 facilitates loading of the MCM2-7 helicase onto chromatin during the assembly of prereplicative complex. PMID: 23093411
11. Data show that And-1 forms a complex with both histone H3 and Gcn5. PMID: 21725360
12. in human cells, hCtf4 plays an essential role in DNA replication and its ability to stimulate the replicative DNA polymerases may contribute to this effect PMID: 20089864
13. Mcm10 is required for chromatin loading of And-1. PMID: 17761813
14. AND-1 coordinates multiple cellular events in S phase and G2 phase. PMID: 19439411
15. Assembly of the Cdc45-Mcm2-7-GINS complex requires the Ctf4/And-1, RecQL4, and Mcm10 proteins. PMID: 19805216

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HGNC: 23170

OMIM: 608126

KEGG: hsa:11169

STRING: 9606.ENSP00000353793

UniGene: Hs.385998