WDHD1

WDHD1 encodes WD repeat and high mobility group box DNA binding protein 1, a nuclear protein involved in DNA replication and cell cycle regulation. It interacts with replication factors like PCNA and regulates origin firing through chromatin remodeling.
WDHD1 is associated with the ATM/ATR DNA damage response pathway. Dysregulation may contribute to genomic instability in cancers, though its specific role in tumorigenesis and potential as a therapeutic target remain under investigation.