Recombinant Mouse C-C motif chemokine 19 protein(Ccl19) (Active)

In Stock
Code CSB-AP001321MO
Product Type Chemokine
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. O70460
Lead Time 5-10 business days
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Epstein-Barr virus-induced molecule 1 ligand chemokine, ELC, Small-inducible cytokine A19
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human mature dendritic cells is in a concentration range of 10-100 ng/ml.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Immunology
Source E.coli
Gene Names Ccl19
Expression Region 26-108aa
Tag Info Tag-Free
Mol. Weight 9.2 kDa
Protein Description Full Length of Mature Protein
PubMed ID 9653094; 15489334
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Function Strongly chemotactic for naive (L-selectinhi) CD4 T-cells and for CD8 T-cells and weakly attractive for resting B-cells and memory (L-selectinlo) CD4 T-cells. May play a role in promoting encounters between recirculating T-cells and dendritic cells and in the migration of activated B-cells into the T-zone of secondary lymphoid tissues. Binds to chemokine receptor CCR7. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.
Subcellular Location Secreted
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Highly expressed by dendritic cells in mesenteric and peripheral lymph nodes. Significant expression in spleen (T cell zone or periarteriolar lymphatic sheath) and Peyer patches. Low expression in thymus.
Database Links

KEGG: mmu:100039053

STRING: 10090.ENSMUSP00000137353

UniGene: Mm.426373

Pathway Chemokine signaling pathway
NF-kappa B signaling pathway

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