Recombinant Mouse C-C motif chemokine 22 protein (Ccl22)

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Code CSB-AP001351MO
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Size $142
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Product Details

Purity
>97% as determined by SDS-PAGE.
Endotoxin
Less than 1.0 EU/μg as determined by LAL method.
Activity
Not Test
Target Names
Uniprot No.
Research Area
Immunology
Alternative Names
Ccl22; Abcd1; Scya22C-C motif chemokine 22; Activated B and dendritic cell-derived; CC chemokine ABCD-1; Small-inducible cytokine A22
Species
Mus musculus (Mouse)
Source
E.Coli
Expression Region
25-92aa
Complete Sequence
GPYGANVEDS ICCQDYIRHP LPSRLVKEFF WTSKSCRKPG VVLITVKNRD ICADPRQVWV KKLLHKLS
Mol. Weight
7.8 kDa
Protein Length
Full Length of Mature Protein
Tag Info
Tag-Free
Form
Liquid or Lyophilized powder
Buffer
0.2 μm filtered concentrated solution in 20 mM PB, pH 7.4, 150 mM NaCl, lyophilized
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
5-10 business days
Datasheet & COA
Please contact us to get it.
Description

The recombinant Mouse Ccl22,Abcd1,Scya22 was expressed with the amino acid range of 25-92. The theoretical molecular weight of the Ccl22,Abcd1,Scya22 protein is 7.8 kDa. The Ccl22,Abcd1,Scya22 protein was expressed in e.coli. The Ccl22,Abcd1,Scya22 coding gene included the Tag-Free, which simplifies the detection and purification processes of the recombinant Ccl22,Abcd1,Scya22 protein in following stages of expression and purification.

Mouse C-C motif chemokine 22 (Ccl22) is a small cytokine belonging to the CC chemokine family. It plays a key role in immune regulation and inflammation. Ccl22 is primarily secreted by dendritic cells, macrophages, and certain other immune cells. Its main function is to attract and modulate the activity of immune cells, particularly T lymphocytes, by binding to its receptor, CCR4. Research areas involving Ccl22 focus on understanding its role in immune responses, inflammation, and various diseases, including autoimmune disorders and cancer. Investigating the molecular mechanisms by which Ccl22 influences immune cell migration and function contributes to the development of potential therapeutic strategies targeting the chemokine system for immunomodulation and disease intervention.

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Target Background

Function
Chemotactic for activated T-lymphocytes. May play an important role in the collaboration of dendritic cells and B-lymphocytes with T-cells in immune responses.
Gene References into Functions
  1. the subset of peritoneal CD11b(+)CD169(+) macrophages increased and CCL22 expression level decreased significantly during the DSS-induced colitis PMID: 28466432
  2. Intratumoral administration of anti-CCL22 antibody inhibited B16F10 melanoma growth. PMID: 28668835
  3. this study shows that intravenous injection of apoptotic cells induces a subsequent increase in CCL22 expression and CCR4+ Treg cells, which contribute to the maintenance of immune homeostasis at least partially by splenic CD8alpha+ CD103+ dendritic cells PMID: 26868141
  4. CCL22-specific antibodies reveal that engagement of two distinct binding domains on CCL22 is required for CCR4-mediated function. PMID: 26683175
  5. CCL22 was localised mainly on the cell surface and or in the cytoplasm. Within sections of omental milky spot micrometastases, CCR4 was recognised on or in gastric cancer cells, constituent cells milky spots, blood cells and blood endothelial cells PMID: 25245466
  6. results show that the IL-4/CCL22/CCR4 axis is involved in the migration of Tregs to osteolytic lesion sites, and attenuates development of lesions by inhibiting inflammatory migration and the production of proinflammatory and osteoclastogenic mediators PMID: 25264308
  7. CCL22 has a role in Treg skin homing to suppress depigmentation PMID: 25634358
  8. CCL22 is a novel mediator of lung inflammation following hemorrhage and resuscitation PMID: 25136780
  9. The immunomodulatory properties of CCL22 could be harnessed for prevention of graft rejection and type 1 diabetes as well as other autoimmune disorders. PMID: 25740943
  10. Data indicate macrophage-derived chemokine CCL22 as an adjuvant could enhance the immune protective effect of NTHi-P6 protein vaccine to an extent. PMID: 25200152
  11. islet expression of CCL22 recruits Tregs and attenuates autoimmune destruction of beta cell PMID: 21737880
  12. Data show that the presence of the Ccr4 and Ccl22 transcripts were detected in brain slices. PMID: 21177120
  13. These results suggest that CCL22 functions to regulate development of experimental autoimmune encephalomyelitis through macrophage chemoattraction and effector function. PMID: 20940325
  14. role of CCL22 for the recruitment of eosinophils during allergic pleurisy PMID: 12629149
  15. functionally increased expression during Salmonella enterica serovar Typhimurium infection of dendritic cells PMID: 15731072
  16. Regulatory elements of the CCL22 gene required to mediate a strong and highly specific expression are included in a 4.1-kb promoter region, with the major elements active in dendritic cells and B cells being located in a small proximal 250-bp region. PMID: 15843561
  17. CCL22 was selectively upregulated in osteoclast-like cells derived from RAW264.7 cells and mouse bone marrow cells upon stimulation with RANKL (receptor activator of nuclear factor-kappaB ligand). PMID: 16821125
  18. IgE appears to be capable of stimulating basophils to produce MDC in the absence of a specific Ag, which may contribute to IgE-mediated and/or Th2-predominant allergic inflammation. PMID: 18832724
  19. When isolated, only natural killer (NK)-containing cellular fractions secrete CCL22, and the same fraction isolated from metastatic Lewis lung carcinoma (LLC)-bearing lungs secrete higher levels. PMID: 19234170
  20. Mice genetically deficient in CCR4 (the receptor for CCL22) show markedly reduced indoleamine dioxygenase (IDO) expression in MLN-DCs and support the involvement of the CCL22/CCR4 axis in IDO induction. PMID: 19843945

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Subcellular Location
Secreted.
Protein Families
Intercrine beta (chemokine CC) family
Tissue Specificity
Expressed by activated splenic B-lymphocytes and dendritic cells. Low expression in lung, thymocytes, lymph node, and unstimulated splenic cells.
Database Links
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