Recombinant Human Granulocyte colony-stimulating factor protein(CSF3) (Active)

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Code CSB-AP002071HU
Product Type Colony Stimulating Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. P09919
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered 10mM sodium acetate buffer, containing 5 % trehalose, pH 4.0 ,lyophilized
Alias G-CSF, Filgrastim, Lenograstim
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine NFS-60 cells is less than 0.1 ng/ml, corresponding to a specific activity of >1.0x107 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA LQEKLCATYK LCHPEELVLL GHSLGIPWAP LSSCPSQALQ LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP
Research Area Immunology
Source E.coli
Gene Names CSF3
Expression Region 31-204aa
Tag Info Tag-Free
Mol. Weight 18.7 kDa
Protein Description Partial of Isoform Short
PubMed ID 3484805; 2423327; 3494801; 15028279; 16625196; 2420009; 8554326; 7685769; 1281794; 7518249; 7685117; 10537111; 16492764
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Function Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.
Subcellular Location Secreted
Protein Families IL-6 superfamily
Database Links

HGNC: 2438

OMIM: 138970

KEGG: hsa:1440

STRING: 9606.ENSP00000225474

UniGene: Hs.2233

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
Hematopoietic cell lineage
IL-17 signaling pathway

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