Recombinant Mouse Thrombopoietin protein(Thpo) (Active)

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Code CSB-AP003451MO
Product Type Colony Stimulating Factor
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. P40226
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4, with 5% Trehalose ,lyophilized
Alias C-mpl ligand, Megakaryocyte colony-stimulating factor, Megakaryocyte growth and development factor, MGDF, Myeloproliferative leukemia virus oncogene ligand
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human MO7e cells is less than 1.0 ng/ml, corresponding to a specific activity of >1.0x106 IU/mg.
Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF
Research Area Cancer
Source E.coli
Gene Names Thpo
Expression Region 22-195aa
Tag Info Tag-Free
Mol. Weight 18.7 kDa
Protein Description Partial
PubMed ID 8202158; 8020099; 7849319; 15489334; 22284746
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Function Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Subcellular Location Secreted
Protein Families EPO/TPO family
Tissue Specificity Found mainly in the liver, kidney and skeletal muscle.
Database Links

KEGG: mmu:21832

STRING: 10090.ENSMUSP00000075756

UniGene: Mm.3943

Pathway Jak-STAT signaling pathway
Hematopoietic cell lineage

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