THPO

The protein corresponding to the gene THPO is thrombopoietin. It is also commonly known as megakaryocyte growth and development factor (MGDF). Thrombopoietin plays a crucial role in regulating the production of platelets. It binds to the c-Mpl receptor on megakaryocyte progenitors, activating multiple signaling pathways such as the JAK - STAT pathway, which promotes megakaryocyte proliferation and differentiation.
Dysregulation of THPO is associated with diseases like thrombocytopenia and thrombocythemia. In drug development, thrombopoietin mimetics have been developed. These drugs can stimulate platelet production and have shown promise in treating platelet - related disorders, improving patients' conditions and reducing the risk of bleeding.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of MO7e cells is 0.4353 - 1.089 ng/mL.

THPO Antibody (CSB-PA005677)

Validated Data

Western Blot analysis of MCF-7 cells using TPO Polyclonal Antibody.

Human Thrombopoietin,TPO ELISA kit (CSB-E04745h)

Validated Data

Code: CSB-E04745h

Size: 96T,5×96T,10×96T

Sensitivity: 1.56 pg/mL

Detection Range: 6.25 pg/mL-400 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following THPO reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

THPO Antibodies

THPO Proteins

THPO ELISA Kits

THPO Antibodies

THPO Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA005677	THPO Antibody	Human	WB, ELISA
CSB-PA023509ZA01HU	THPO Antibody	Homo sapiens	ELISA, WB (ensure identification of antigen)

THPO Antibodies for Rattus norvegicus (Rat)

Code	Product Name	Species Reactivity	Application
CSB-PA07649A0Rb	Thpo Antibody	Rat, Mouse, Human	ELISA, WB
CSB-PA07649B0Rb	Thpo Antibody, HRP conjugated	Rat	ELISA

THPO Proteins

THPO Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP023509HU CSB-BP023509HU CSB-MP023509HU CSB-EP023509HU-B	Recombinant Human Thrombopoietin (THPO)，partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP023509HU	Recombinant Human Thrombopoietin (THPO)，partial	E.coli
CSB-AP003971HU	Recombinant Human Thrombopoietin (THPO) (Active)	Mammalian cell
CSB-EP023509HUc7	Recombinant Human Thrombopoietin (THPO), partial	E.coli
CSB-MP023509HU(A4)	Recombinant Human Thrombopoietin (THPO) (Active)	Mammalian cell
CSB-BP023509HU(A4)	Recombinant Human Thrombopoietin (THPO)	Baculovirus

THPO Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP023509PI CSB-EP023509PI CSB-BP023509PI CSB-MP023509PI CSB-EP023509PI-B	Recombinant Pig Thrombopoietin (THPO), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

THPO Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP023509MO CSB-EP023509MO CSB-BP023509MO CSB-MP023509MO CSB-EP023509MO-B	Recombinant Mouse Thrombopoietin (Thpo)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-AP003451MO	Recombinant Mouse Thrombopoietin protein (Thpo), partial (Active)	E.Coli

THPO Proteins for Canis lupus familiaris (Dog) (Canis familiaris)

Code	Product Name	Source
CSB-YP023509DO CSB-EP023509DO CSB-BP023509DO CSB-MP023509DO CSB-EP023509DO-B	Recombinant Dog Thrombopoietin (THPO)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

THPO Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP023509RA CSB-EP023509RA CSB-BP023509RA CSB-MP023509RA CSB-EP023509RA-B	Recombinant Rat Thrombopoietin (Thpo)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-RP076444r	Recombinant Rat Thrombopoietin (Thpo), partial	E.coli