DDX53 Antibody

Code CSB-PA773024ZA01HU
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) DDX53 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
CAGE antibody; Cancer associated gene protein antibody; Cancer-associated gene protein antibody; Cancer/testis antigen 26 antibody; CT26 antibody; DDX53 antibody; DDX53_HUMAN antibody; DEAD (Asp Glu Ala Asp) box polypeptide 53 antibody; DEAD box protein 53 antibody; DEAD box protein CAGE antibody; Probable ATP dependent RNA helicase DDX53 antibody; Probable ATP-dependent RNA helicase DDX53 antibody
Raised in
Species Reactivity
Homo sapiens
Recombinant Homo sapiens DDX53 protein
Immunogen Species
Homo sapiens (Human)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time
Made-to-order (12-14 weeks)

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Target Background

Gene References into Functions
  1. A novel role of DDX53 in regulating cancer stem cell-like properties by binding to SOX-2.DDX53 directly regulates the SOX-2 expression in drug-resistant melanoma cells. PMID: 28535666
  2. DDX53 promotes stem cell-like properties, autophagy, and confers resistance to anti-cancer drugs in breast cancer cells. PMID: 28152297
  3. Results provide evidence that miR-30a forms a positive feedback loop with CAGE to regulate the expression of p53 confering resistance to anti-cancer drugs. PMID: 26912082
  4. miR-217-CAGE feedback loop serves as a target for overcoming resistance to various anti-cancer drugs, including EGFR and HER2 inhibitors. PMID: 26863629
  5. Results show the direct regulation of CAGE expression by HDAC3 and that HDAC3-CAGE axis regulates the activation of EGFR. HDAC3 targets CAGE to regulate the tumorigenic potential and angiogenic potential of cancer cells. PMID: 26883907
  6. CAGE induced the interaction between histone deacetylase 2 (HDAC2) and Snail, which exerted a negative effect on p53 expression in neoplastic cells; CAGE confers drug resistance by regulating expression of p53 through HDAC2. PMID: 20534591
  7. CAGE is expressed in a variety of cancers but not in normal tissues except testis, and might play a role in cellular proliferation. PMID: 11922625
  8. results suggest that the methylation status of the CpG sites of CAGE determines its expression, and that hypomethylation of CAGE precedes the development of gastric cancer and hepatocellular carcinoma PMID: 12849980
  9. CAGE promotes motility of cancer cells through activation of focal adhesion kinase (FAK). PMID: 17028776
  10. Hypomethylated CAGE promoter CpG islands are frequently involved in uterine cervical carcinogenesis. PMID: 17341616
  11. The CAGE gene is widely expressed in various cancer tissues and cancer cell lines. PMID: 18388483

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Subcellular Location
Protein Families
DEAD box helicase family
Tissue Specificity
Expressed in testis. Wide expression in various cancer tissues and cancer cell lines.
Database Links

HGNC: 20083

KEGG: hsa:168400

STRING: 9606.ENSP00000368667

UniGene: Hs.434416

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