dpp Antibody

1. analysis of phenotype caused by misexpression of Wg, a negative regulator of eye development, using GMR17E04-Gal4, GMR18D08-Gal4 with existing dpp-Gal4 driver, which suggests the need for revisiting misexpression studies with Gal4 drivers PMID: 29702674
2. Loss of Pngl results in a severe decrease in the level of Dpp homodimers and abolishes BMP autoregulation in the visceral mesoderm mediated by Dpp and Tkv homodimers. Loss of Pngl results in developmental midgut defects reminiscent of midgut-specific loss of BMP signaling. PMID: 28826503
3. The authors find that both arms of the TFGb signaling pathways specifically instruct the pale photoreceptor subset in R8. The Activin arm utilizes the three ligands dActb, Daw, and Myo non-redundantly to activate Babo and downstream dSmad2 in R8, while the BMP arm signals by way of Dpp and Gbb to Tkv and Mad. PMID: 28853393
4. Dpp regulates growth and proliferation rates equally in central and lateral regions of the developing wing appendage and reduced levels of Dpp affects similarly the width and length of the resulting wing. PMID: 28675372
5. Here, by removing dpp from the stripe at different time points, the authors show that the dpp stripe source is indeed required for wing disc growth, also during third instar larval stages. PMID: 28675373
6. With two independent conditional alleles of dpp, the authors find that the stripe of Dpp is essential for wing growth. The authors then show that this requirement, but not patterning, can be fulfilled by uniform, low level, Dpp expression. Thus, the stripe of Dpp ensures that signalling remains above a pro-growth threshold, while at the same time generating a gradient that patterns cell fates. PMID: 28675374
7. Study provide evidence of yet another mechanism by which Dpp regulates the expression of its target retinal retinal determining (RD) genes independent of its bona fide transcriptional regulator specifically during induction of ectopic eyes. Apart from previously known transcriptional activation of the RD genes, Dpp simultaneously triggers another signaling cascade that involves dTak1-mediated activation of JNK. PMID: 27270790
8. we found that the Dpp target gene sal is only expressed in peripodial epithelium (DP, also known as pseudostratified columnar epithelia) , not in PE cells, also known as squamous epithelia, although pMad is present in the PE. PMID: 27452716
9. Here we provide evidence that although wild type CtBP negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP in Dpp signaling in vivo. PMID: 29225171
10. Dpp activates signaling cascade involving dTak1 and JNK, to induce ectopic Mmp1 expression. PMID: 28696218
11. ECM over planar cell polarity mutant cells had reduced levels of laminin, Dally and Dlp, and whereas Dpp-receiving ASP cytonemes navigated in the Dally layer and required Dally (but not Dlp), FGF-receiving ASP cytonemes navigated in the Dlp layer, requiring Dlp (but not Dally). PMID: 27591355
12. The authors show that Pent internalises the Dpp co-receptors, the glypicans Dally and Dally-like protein (Dlp), and propose that this internalisation is important in the establishment of a long range Dpp gradient. PMID: 27269283
13. The expression of optix is activated by Dpp and repressed by the Spalt proteins, becoming restricted to the most anterior region of the wing blade. PMID: 28760811
14. En forms a complex with Nejire (Nej), the Drosophila ortholog of histone acetyltransferase CBP/p300, and directs Nej to this cis-regulatory region where Nej functions as the co-activator for dpp expression. PMID: 28928281
15. Basement membrane elimination, in contrast, attenuated signaling by bone morphogenetic protein/transforming growth factor beta ligand Dpp, which was not efficiently retained within the tissue and escaped to the body cavity. PMID: 28697337
16. This report provides a genetic analysis of primary nociceptive neuron mechanisms that promote sensitization in response to injury. Drosophila melanogaster larvae whose primary nociceptive neurons were reduced in levels of specific components of the BMP signaling pathway, were injured and then tested for nocifensive responses to a normally subnoxious stimulus. PMID: 28855331
17. Dad and Dpp activity is dynamically regulated in the adult Drosophila middle midgut. PMID: 27570230
18. Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr) pathway in the lateral epidermis for sustained dpp expression in the LE. Specifically, we demonstrate that Egfr pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling PMID: 28628612
19. In this work, we have explored the disc autonomous function of TGFbeta that promotes wing imaginal disc growth. We have studied the genetic interactions between TGFbeta signaling and other pathways regulating wing disc growth, such as the Insulin and Hippo/Salvador/Warts pathways, as well as cell cycle regulators. PMID: 28315837
20. During normal development, Dpp represses hth and tsh ensuring that the progenitor state is transient. However, cells in which Hth+Tsh expression is forcibly maintained use Dpp to enhance their proliferation. PMID: 27502436
21. Here we demonstrate that each prostate-like secondary cell (SC) in the paired adult Drosophila melanogaster male accessory glands contains approximately ten large DCGs, which are loaded with the Bone Morphogenetic Protein (BMP) ligand Decapentaplegic (Dpp). PMID: 27727275
22. disruption of dpp expression causes apoptosis in peripodial cells and underlying disc proper cells PMID: 26500262
23. we elucidate the genetic network elicited by Snoo and Dpp activity. These results illustrate a regulatory mechanism that translates intrinsic potential and extrinsic cues into the facultative stem cell features of differentiated progenitors. PMID: 26942411
24. During oogenesis lgd loss of function causes ectopic activation of the Drosophila BMP signalling pathway. PMID: 25804739
25. in the absence of Dpp spreading, wing disc patterning is lost; however, lateral cells still divide at normal rates PMID: 26550827
26. Cullin-2 protein present in the somatic cells is involved in a non cell-autonomous regulation of the extent of Dpp signaling and thus controls the differentiation of GSCs to cystoblasts PMID: 26206612
27. Dpp and Gbb are produced by enterocytes and act in conjunction to promote intestinal stem cell self-renewal by antagonizing Notch signaling. PMID: 24618900
28. Mad linker phosphorylations control the intensity and range of the BMP-activity gradient in developing Drosophila tissues. PMID: 25377173
29. Thickveins (Tkv; a type I receptor of Dpp) is highly expressed in stromal cells next to Dpp-producing cells and functions to remove excess Dpp outside the stem cell niche. PMID: 26008746
30. Authors studied BMP-dependent gene regulation during Drosophila oogenesis by following the signal transmission from Dpp to its target broad (br), a gene with a crucial function in eggshell patterning and identified regulatory sequences that account for expression of both brk and br, and connect these to the transcription factors of the pathway. PMID: 25704512
31. Dpp/Gbb signaling is required for normal intestinal regeneration during infection. PMID: 25553980
32. Decapentaplegic (DPP) and JNK form a coherent feed-forward loop that controls the specification and differentiation of leading edge cells during Drosophila melanogaster dorsal closure. PMID: 25601405
33. Dpp plays a dual role during dorsal closure. It cooperates with JNK in stimulating cell migration and also prevents JNK from inducing apoptosis. PMID: 25307481
34. novel mechanisms by which Dpp affects the cellular differentiation of wing-veins. PMID: 24591046
35. Loss of Bar from the undifferentiated retinal precursor cells leads to ectopic expression of Prospero and dPax2, two transcription factors essential for cone cell specification, resulting in excess cone cell differentiation. PMID: 24505414
36. The signaling dynamics of the morphogen Dpp, one of several Drosophila factors controlling morphogenetic growth, was measured in the developing eye. PMID: 24757005
37. These data reveal novel mechanisms by which post-translational regulation of Scw can modulate Dpp signaling activity. PMID: 24560644
38. We propose that developmental BMP signaling potentiates NMJs for rapid activity-dependent structural plasticity that is achieved by muscle release of retrograde signals that regulate local presynaptic actin cytoskeletal dynamics. PMID: 24647957
39. Genetic loss-of-function conditions for diaphanous, shibire, neuroglian, and capricious perturbed cytonemes by reducing their number or only the synapses they make with cells they target, and reduced cytoneme-mediated transport of Dpp and Dpp signaling. PMID: 24385607
40. Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling. PMID: 23891114
41. Dpp signaling is required for copper cell regeneration and gut compartmentalization. PMID: 23810561
42. optix functions together with hh to regulate dpp in the morphogenetic furrow, serving as a link between the RD network and the patterning pathways controlling normal retinal development PMID: 23792115
43. spatial distribution of Dpp is tightly regulated at the extracellular level allowing diffusible ligands to form elaborate wing vein patterns PMID: 22542596
44. Dpp-induced Egfr signaling triggers postembryonic wing development in Drosophila. PMID: 23479629
45. data demonstrate Dpp signaling is primarily activated in enterocytes and Dpp is expressed specifically in tracheal cells that reach the intestinal cells through the visceral muscles PMID: 23369712
46. We propose that the double role of KAY-alpha in the two transcriptional loops controlling Drosophila circadian behavior brings precision and stability to their oscillations PMID: 23175847
47. Dpp transport occurs by simple, rapid diffusion in the extracellular space. PMID: 22445299
48. dpp controls morphogenesis of the ventral adult head through expression in the eye-antennal disc by a 3.5 kb enhancer in the 5' end of the gene. We recovered a 15 bp deletion mutation within this enhancer that identified a homeotic response element. PMID: 22824425
49. collagen IV functions to immobilize free Dpp in the Drosophila embryo PMID: 22733779
50. Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient PMID: 22745309

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KEGG: dme:Dmel_CG9885

STRING: 7227.FBpp0077451

UniGene: Dm.4767