E2f1 Antibody

1. dE2F1b is a novel member of the E2F family, revealing a previously unappreciated complexity in the Drosophila RB/E2F network. PMID: 29420631
2. specific alternate transcripts of activator E2F, dE2F1, may have a dual function on cell cycle progression and cannot simply be viewed as a pro-proliferative transcription factor PMID: 26859702
3. These findings identify a key function of E2F in skeletal muscle required for animal viability, and illustrate how the cell cycle regulator is repurposed in post-mitotic cells. PMID: 26823289
4. also demonstrated that an optimum level of dLin52 is needed for dE2F1/2 activity on the hid promoter PMID: 24863159
5. Loss of dE2F compromises mitochondrial function. PMID: 24286825
6. Inappropriate accumulation of E2f1 protein during S phase triggers the elimination of potentially hyperplastic cells via apoptosis in order to ensure normal development of rapidly proliferating tissues. PMID: 22916021
7. endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1 PMID: 22037307
8. coexpression of miR-11 limits the proapoptotic function of its host gene, dE2f1, upon DNA damage by directly modulating a dE2F1-dependent apoptotic transcriptional program PMID: 21856777
9. report here that dE2F1 promotes ionizing radiation-induced p53-independent apoptosis in larval imaginal discs PMID: 20659447
10. Screening strategy for studying regulation of the dE2F/RBF pathway in vivo. PMID: 19546319
11. dE2F1 has a role in nurse cell apoptosis PMID: 12464435
12. Transcriptional repressor functions of E2F1 & E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. The relative functional contributions of E2F1 & E2F2 to gene expression & cell cycle control depend on the developmental context. PMID: 12612083
13. Data show that dE2F1 is important for the normal pattern of DNA damage-induced apoptosis in Drosophila wing discs. PMID: 16198289
14. Apoptosis inhibitor-5/antiapoptosis clone-11 (Api5/Aac11) is a critical determinant of dE2F1-induced apoptosis in vivo and in vitro. PMID: 17112319
15. We examined the process of cell cycle exit in Drosophila wings and eyes and discovered that cell cycle exit can be prevented or even reversed in terminally differentiating cells by the simultaneous activation of E2F1 and either CycE/cdk2 or CycD/cdc4. PMID: 17419999
16. In addition to de2f2, the loss of a DEAD box protein Belle (Bel) also rescues proliferation of de2f1 mutant cells. PMID: 17923695
17. p53 is required for dE2F-dependent apoptosis in the response to DNA damage, but it is not required for E2F-dependent apoptosis caused by the inactivation of rbf1. PMID: 18688282
18. Abnormal expansion of polyQ may potentiate innate androgen-dependent association of AR with Rb through aberrant E2F transactivation caused by suppressed histone deacetylation. PMID: 19237573

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KEGG: dme:Dmel_CG6376

STRING: 7227.FBpp0083516

UniGene: Dm.7299