Gnai3 Antibody

Datasheet

Code	CSB-PA009591XA01RA
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Target Background

Product Details

Full Product Name

Rabbit anti-Rattus norvegicus (Rat) Gnai3 Polyclonal antibody

Uniprot No.

P08753

Target Names

Gnai3

Alternative Names

Gnai3 antibody; Gnai-3Guanine nucleotide-binding protein G(i) subunit alpha antibody; G(i) alpha-3 antibody

Raised in

Rabbit

Species Reactivity

Rattus norvegicus (Rat)

Immunogen

Recombinant Rattus norvegicus (Rat) Gnai3 protein

Immunogen Species

Rattus norvegicus (Rat)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB (ensure identification of antigen)

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Lead Time

Made-to-order (14-16 weeks)

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Target Background

Function

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels. Stimulates the activity of receptor-regulated K(+) channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.

Gene References into Functions

Nitric oxide decreased the enhanced expression of Gialpha-2/3 proteins and hyperproliferation of Vascular smooth muscle cells from spontaneously hypertensive rats by cGMP-independent mechanism. PMID: 28692698
These results indicate that NPR-C activation by C-ANP4-23 attenuates the enhanced levels of cell cycle proteins through the inhibition of enhanced expression of Gialpha proteins. PMID: 24155894
Results suggest that the suppression of Dopamine-2 (D2) receptor short (D2S)-regulated Gi3 inhibition of Gs protein may be one of the mechanisms controlling estradiol (E(2)-activated prolactin (PRL) synthesis and cell proliferation in lactotropes. PMID: 22573829
studies suggest a possible role for zymogen granule-associated G(alpha)(i3) in zymogen granule-plasma membrane fusion PMID: 12038977
Suggest role for oxidative stress in high glucose-induced decreased expression of Gnai2/3 and adenylyl cyclase signaling in vascular smooth muscle cells. PMID: 18441196

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Subcellular Location

Cytoplasm. Cell membrane; Lipid-anchor. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Protein Families

G-alpha family, G(i/o/t/z) subfamily

Tissue Specificity

Ubiquitous.

Database Links

KEGG: rno:25643

STRING: 10116.ENSRNOP00000026710

UniGene: Rn.4368

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Related pathways

cAMP signaling pathway Chemokine signaling pathway Estrogen signaling pathway Melanogenesis Gap junction Apelin signaling pathway cGMP-PKG signaling pathway Rap1 signaling pathway Sphingolipid signaling pathway Glutamatergic synapse

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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Gnai3 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background