Grem1 Antibody

Code CSB-PA009892ZA01RA
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Grem1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
Grem1 antibody; Cktsf1b1 antibody; Drm antibody; Gremlin-1 antibody; Cysteine knot superfamily 1 antibody; BMP antagonist 1 antibody; Down-regulated in Mos-transformed cells protein antibody
Raised in
Species Reactivity
Rattus norvegicus
Recombinant Rat Gremlin-1 (Grem1) (25-184AA)
Immunogen Species
Rattus norvegicus (Rat)
Purification Method
Protein A/G
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Tested Applications
ELISA, WB (ensure identification of antigen)
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables
① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee
① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time

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Target Background

Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner. Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed.
Gene References into Functions
  1. gremlin1 promotes hepatic stellate cell activation and hepatic fibrogenesis through impairment of the balance between transforming growth factor beta and bone morphogenetic protein 7 signaling pathways. PMID: 27863390
  2. The therapeutic mechanism of Danshao Huaxian capsule in hepatic fibrosis may be associated with inhibition of the expression of Gremlin and up-regulation of the expression of BMP-7. PMID: 25356047
  3. GREM1 affects follicle transition in cultured ovaries, but is not normally present in primordial and early-stage developing follicles. PMID: 24614542
  4. Notch pathway gene expression is elevated in diabetic nephropathy, co-incident with Gremlin, and may contribute to the pathogenesis of this dise PMID: 17980714
  5. Gremlin plays a part in the development of pathological phenotypic changes of adult vascular smooth muscle cell. PMID: 18086474
  6. The bone morphogenetic protein antagonist gremlin promotes vascular smooth muscle cell apoptosis. PMID: 19142012

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Subcellular Location
Protein Families
DAN family
Tissue Specificity
Highly expressed in the brain, kidney, spleen, and testis and weakly expressed in the lung and liver. Predominantly expressed in differentiated cells as neurons in brain, type I cells in lung and globlet cells in intestine.
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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