GREM1 encodes the protein Gremlin-1, also known as DAN domain-containing protein 4. It is a secreted bone morphogenetic protein (BMP) antagonist. Gremlin-1 binds to BMPs, preventing their interaction with BMP receptors and thus inhibiting BMP signaling. This protein is involved in multiple cellular processes such as cell proliferation, differentiation, and apoptosis.
Gremlin-1 is implicated in various diseases, including cancer, fibrosis, and diabetic nephropathy. In cancer, it promotes tumor growth and metastasis. Currently, there is ongoing research to develop drugs targeting Gremlin-1, aiming to block its function and potentially treat related diseases effectively.
GREM1 Antibody (CSB-PA009892LA01HU)
Validated Data
IHC image of CSB-PA009892LA01HU diluted at 1:300 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of CSB-PA009892LA01HU diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Human Gremlin-1(GREM1) ELISA kit (CSB-EL009892HU)
Validated Data
Code: CSB-EL009892HU
Size: 96T,5×96T,10×96T
Sensitivity: 0.039 ng/mL
Detection Range: 0.156 ng/mL-10 ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following GREM1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
GREM1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA168659 | GREM1 Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA009892LA01HU | GREM1 Antibody | Human | ELISA, IHC |
CSB-PA009892LB01HU | GREM1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA009892LC01HU | GREM1 Antibody, FITC conjugated | Human | |
CSB-PA009892LD01HU | GREM1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA009892MA1HU | GREM1 Recombinant Monoclonal Antibody | Human | ELISA, IHC |
GREM1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP009892HU CSB-EP009892HU CSB-BP009892HU CSB-MP009892HU CSB-EP009892HU-B |
Recombinant Human Gremlin-1 (GREM1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GREM1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL009892HU | Human Gremlin-1(GREM1) ELISA kit | serum, plasma, cell culture supernates, tissue homogenates, cell lysates | 0.039 ng/mL |