S Antibody

Datasheet

Code	CSB-PA321366ZA01HIT
Size	US$299
Image	Western Blot Positive WB detected in Recombinant protein All lanes: S antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 17.2 kDa Observed band size: 17 kDa
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Target Background

Product Details

Uniprot No.

P15423

Target Names

Alternative Names

Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein), S

Species Reactivity

Human coronavirus 229E

Immunogen

Recombinant Human coronavirus 229E Spike glycoprotein(S),partial (785-873aa)

Immunogen Species

Human coronavirus 229E

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Protein G

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

The S antibody is produced by immunizing a rabbit with recombinant human coronavirus 229E Spike glycoprotein (S) (785-873aa), which triggers the production of tailored IgG antibodies by the rabbit's B lymphocytes. Following this, the polyclonal S antibody is thoroughly purified from the rabbit's serum utilizing the protein G method. This S antibody is suitable for the detection of human coronavirus 229E S protein in ELISA and WB experiments.

The main role of the human coronavirus 229E spike glycoprotein (S) is to facilitate viral entry into host cells. This S protein binds to ACE2 on the surface of human cells, which triggers the fusion of the viral envelope with the host cell membrane, allowing the virus to enter the cell. The S protein is a key determinant of host cell specificity and is a target for the host's immune response.

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Target Background

Function

S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.

Gene References into Functions

Two amino acid substitutions (R642M and N714K) in the S protein of HCoV-229E clinical isolates altered their sensitivity to a cathepsin L inhibitors and their tropism towards endosomes. PMID: 27733646
The highly homologous C-terminal parts of the NL63-S1 subunits in conjunction with distinct amino acids in the central regions of these proteins confer recognition of ACE2 and CD13, respectively. PMID: 16912312

Subcellular Location

Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein.

Protein Families

Alphacoronaviruses spike protein family

Database Links

KEGG: vg:918758

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