| Code | CSB-PA321366ZA01HIT |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
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| Uniprot No. | P15423 |
| Target Names | S |
| Alternative Names | Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein), S |
| Species Reactivity | Human coronavirus 229E |
| Immunogen | Recombinant Human coronavirus 229E Spike glycoprotein(S),partial (785-873aa) |
| Immunogen Species | Human coronavirus 229E |
| Conjugate | Non-conjugated |
| Clonality | Polyclonal |
| Isotype | IgG |
| Purification Method | Protein G |
| Concentration | It differs from different batches. Please contact us to confirm it. |
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Protocols | ELISA Protocol Western Blotting(WB) Protocol |
| Troubleshooting and FAQs | Antibody FAQs |
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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| Function (From Uniprot) |
S1 region attaches the virion to the cell membrane by interacting with host ANPEP/aminopeptidase N, initiating the infection. Binding to the receptor probably induces conformational changes in the S glycoprotein unmasking the fusion peptide of S2 region and activating membranes fusion. S2 region belongs to the class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes. |
| Gene References into Functions |
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| Subcellular Location | Virion membrane; Single-pass type I membrane protein. Host endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. |
| Protein Families | Alphacoronaviruses spike protein family |
| Database Links |
KEGG: vg:918758 |
