SPHK1 Antibody

Code CSB-PA122854XA01DOA
Size Pls inquire
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Product Details

Full Product Name Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) SPHK1 Polyclonal antibody
Uniprot No. Q8L7L1
Target Names SPHK1
Alternative Names SPHK1 antibody; At4g21540 antibody; F18E5.160 antibody; Sphingosine kinase 1 antibody; EC antibody
Raised in Rabbit
Species Reactivity Arabidopsis thaliana
Immunogen Recombinant Arabidopsis thaliana SPHK1 protein
Immunogen Species Arabidopsis thaliana (Mouse-ear cress)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Protein A/G
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB (ensure identification of antigen)
Protocols ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Value-added Deliverables ① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);
Quality Guarantee ① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;
Lead Time Made-to-order (14-16 weeks)

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Target Background

(From Uniprot)
Involved in the production of sphingolipid metabolites. Phosphorylates sphingosine and various sphingoid long-chain base (LCB) products, such as phytosphingosine (PHS, 4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine, D-erythro-dihydrosphingosine and D,L-threo-dihydrosphingosine. Is required for abscisic acid (ABA) signaling that mediates stomatal closure, inhibition of seed germination and root elongation. May function upstream of PLDALPHA1 and phosphatidic acid (PA) in an amplification response to ABA that mediates stomatal closure.
Gene References into Functions
  1. Deletion of amino acids (182)VSGDGI(187) perturbed PA-AtSPHK1 binding, indicating an essential role of these six amino acids in PA-AtSPHK1 binding. PMID: 29783183
  2. findings indicate a role of SPHK1 in modulating FB1-triggered cell death via SA and JA pathway interactions. PMID: 28846870
  3. Sphingosine kinase 1 phosphorylates sphingosine-1-phosphate and phytosphingosine-1-phosphate, and is coordinately regulated with sphingosine-1-phosphate phosphatase. PMID: 18557834
Subcellular Location Vacuole membrane; Peripheral membrane protein. Note=Associated with the tonoplast.
Tissue Specificity Highly expressed in stems and flowers and at lower levels in roots, leaves and siliques.
Database Links

KEGG: ath:AT4G21540

STRING: 3702.AT4G21540.1

UniGene: At.32620

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