TRBC2 Antibody

Datasheet

Code	CSB-PA024292ZA01HU
Size	US$299
Image	Western Blot Positive WB detected in Recombinant protein All lanes: TRBC2 antibody at 1:2000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 19.7 kDa Observed band size: 20 kDa
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Target Background

Product Details

Uniprot No.

A0A5B9

Target Names

TRBC2

Alternative Names

T-cell receptor beta-2 chain C region, TRBC2, TCRBC2

Species Reactivity

Homo sapiens

Immunogen

Recombinant Homo sapiens TRBC2 protein (1-129aa)

Immunogen Species

Homo sapiens

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Protein G

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, WB

Protocols

ELISA Protocol
Western Blotting(WB) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Description

To generate the TRBC2 polyclonal antibody, a series of steps are followed. A rabbit undergoes multiple rounds of immunization with a recombinant human TRBC2 protein (1-129aa) until a satisfactory antibody titer is reached. Subsequently, the rabbit's blood is collected, and the antibodies are isolated from the serum using protein G. The functionality of the resulting TRBC2 antibody is rigorously assessed in both ELISA and WB applications, affirming its specific reactivity with the human TRBC2 protein.

TRBC2 is one of the constant (C) region genes of the TCR beta chain. TRBC2, along with other TCR components, contributes to the formation of a functional TCR complex, allowing T cells to identify and respond to foreign pathogens or abnormal cells.

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Target Background

Function

Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.

Subcellular Location

Cell membrane.

Database Links

HGNC: 12157

OMIM: 615445

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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TRBC2 Antibody

Product Details

Related Products

Customer Reviews and Q&A

Target Background