Wnt2 Antibody

1. Transient expression of WNT2 promotes somatic cell reprogramming by inducing beta-catenin nuclear accumulation. PMID: 27211212
2. Study indicates essential roles for Wnt2 and Wnt3 in chronic restraint stress-induced depression-like behaviors and antidepressant. PMID: 27622936
3. Wnt 2 levels were markedly down-regulated by retinoic acid in pancreatic stellar cells and chronic pancreatitis. PMID: 26556479
4. We propose that the WNT2/CTNNB1 pathway regulates CX43 expression and gap junction intercellular communication in granulosa cells by modulating CTNNB1 stability and localization in adherens junctions PMID: 23843235
5. Pdgf signaling potentiates Wnt2-Wnt7b signaling to promote high levels of Wnt activity in mesenchymal progenitors that is required for proper development of endoderm-derived organs, such as the lung PMID: 22949635
6. Expression of WNT2 in pancreatic cancer cells suppresses anoikis, enhances anchorage-independent sphere formation, and increases metastatic propensity in vivo. PMID: 22763454
7. Wnt2 plays strong positive stage-specific role in cardiogenesis through non-canonical Wnt pathway in murine ES cells. PMID: 22146296
8. show that Wnt2 signaling is necessary and sufficient for activation of a transcriptional and signaling network critical for smooth muscle specification and differentiation including myocardin/Mrtf-B and the signaling factor Fgf10 PMID: 21704027
9. Wnt2 expression is downregulated at lung bud stage in the nitrofen model. Optical projection tomography is potentially a useful approach to visualize both gene expression and morphology during very early stages of lung development. PMID: 21034933
10. The canonical WNT signaling pathway is intact in mouse granulosa cells and that WNT2 can act through beta-catenin, likely downstream of FZD9, to regulate DNA synthesis. PMID: 20107203
11. Results identify Wnt2 as a novel regulator of dopaminergic progenitors and dopaminergic neuron development. PMID: 20018874
12. Wnt2 works in a feedforward transcriptional loop with Gata6 to regulate posterior cardiac development. PMID: 20159597
13. Upregulation by GATA6 in differentiating embryonal carcinoma cells is mediated by the direct binding of GATA-factor(s) to the Wnt2 promoter, suggesting Wnt2 is an immediate downstream target of GATA-factor regulation during early cardiogenesis. PMID: 16621466
14. Wnt2 coordinates the commitment of mesoderm to hematopoietic, endothelial, and cardiac lineages in embryoid bodies PMID: 17098737
15. FMR1, MECP2, and WNT2 expression were drastically down regulated in the Fragile X mouse brain. PMID: 19138667
16. Study revealed new domains of expression for Wnt2, Wnt2b, Wnt5b, Wnt6, Wnt7b, Wnt9a, Wnt10a, Wnt10b, Wnt11 and Wnt16, in the limb. PMID: 19185060
17. Data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut. PMID: 19686689

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KEGG: mmu:22413

STRING: 10090.ENSMUSP00000010941

UniGene: Mm.33653