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| Code | CSB-PA305800ZA01FKZ |
| Size | US$299 |
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The production of the aur polyclonal antibody is a methodical process that begins with the repeated immunization of a rabbit using recombinant Staphylococcus aureus Zinc metalloproteinase aureolysin (aur) (210-509aa). This immunization is conducted until an adequate antibody titer is achieved. Following this, the rabbit's blood is collected, and the antibodies are purified from the serum using protein A/G. The functionality of the resulting aur antibody is extensively evaluated through ELISA and WB applications, confirming its specific reactivity with the Staphylococcus aureus aur protein.
Aureolysin, a secreted metallopeptidase, is a major virulence factor in Staphylococcus aureus. It enhances pathogenicity by promoting a shift from biofilm formation to a more invasive phenotype and aids in nutrient acquisition from host proteins. Additionally, it breaks down the human antimicrobial peptide LL-37, cleaves complement protein C3, and releases chemoattractant C5a to evade complement-mediated neutrophil attack.
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