Human Bone morphogenetic protein 3B(GDF10) ELISA kit

Code CSB-EL009343HU
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
growth differentiation factor 10
Alternative Names
BIP ELISA Kit; BMP 3b ELISA Kit; BMP-3b ELISA Kit; BMP3B ELISA Kit; BMP3B_HUMAN ELISA Kit; Bone inducing protein ELISA Kit; Bone morphogenetic protein 3b [Precursor] ELISA Kit; Bone morphogenetic protein 3b ELISA Kit; Bone-inducing protein ELISA Kit; GDF 10 ELISA Kit; GDF-10 ELISA Kit; Gdf10 ELISA Kit; growth differentiation factor 10 ELISA Kit; Growth/differentiation factor 10 ELISA Kit
Abbreviation
GDF10
Uniprot No.
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
23.5 pg/mL-1500 pg/mL
Sensitivity
5.8 pg/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Signal Transduction
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This Human GDF10 ELISA Kit was designed for the quantitative measurement of Human GDF10 protein in serum, plasma, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 23.5 pg/mL-1500 pg/mL and the sensitivity is 5.8 pg/mL.

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Target Background

Function
(From Uniprot)
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Gene References into Functions
  1. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
  2. GDF10 is a stroke-induced signal for axonal sprouting and functional recovery. PMID: 26502261
  3. new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha PMID: 18077449
  4. BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs. PMID: 18949431
Subcellular Location
Secreted.
Protein Families
TGF-beta family
Tissue Specificity
Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
Database Links

HGNC: 4215

OMIM: 601361

KEGG: hsa:2662

STRING: 9606.ENSP00000224605

UniGene: Hs.2171

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