GDF10 Antibody, Biotin conjugated

Code CSB-PA009343LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GDF10 Polyclonal antibody
Uniprot No.
Target Names
GDF10
Alternative Names
BIP antibody; BMP 3b antibody; BMP-3b antibody; BMP3B antibody; BMP3B_HUMAN antibody; Bone inducing protein antibody; Bone morphogenetic protein 3b [Precursor] antibody; Bone morphogenetic protein 3b antibody; Bone-inducing protein antibody; GDF 10 antibody; GDF-10 antibody; Gdf10 antibody; growth differentiation factor 10 antibody; Growth/differentiation factor 10 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Growth/differentiation factor 10 protein (369-478AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Gene References into Functions
  1. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
  2. GDF10 is a stroke-induced signal for axonal sprouting and functional recovery. PMID: 26502261
  3. new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha PMID: 18077449
  4. BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs. PMID: 18949431
Subcellular Location
Secreted.
Protein Families
TGF-beta family
Tissue Specificity
Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
Database Links

HGNC: 4215

OMIM: 601361

KEGG: hsa:2662

STRING: 9606.ENSP00000224605

UniGene: Hs.2171

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