GDF10 Antibody

Code CSB-PA009343LA01HU
Size US$166
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Image
  • Western Blot
    Positive WB detected in: Rat brain tissue
    All lanes: GDF10 antibody at 4.5μg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 54 kDa
    Observed band size: 54 kDa

  • IHC image of CSB-PA009343LA01HU diluted at 1:200 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • IHC image of CSB-PA009343LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) GDF10 Polyclonal antibody
Uniprot No.
Target Names
GDF10
Alternative Names
BIP antibody; BMP 3b antibody; BMP-3b antibody; BMP3B antibody; BMP3B_HUMAN antibody; Bone inducing protein antibody; Bone morphogenetic protein 3b [Precursor] antibody; Bone morphogenetic protein 3b antibody; Bone-inducing protein antibody; GDF 10 antibody; GDF-10 antibody; Gdf10 antibody; growth differentiation factor 10 antibody; Growth/differentiation factor 10 antibody
Raised in
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant Human Growth/differentiation factor 10 protein (369-478AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The GDF10 Antibody (Product code: CSB-PA009343LA01HU) is Non-conjugated. For GDF10 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA009343LB01HU GDF10 Antibody, HRP conjugated ELISA
FITC CSB-PA009343LC01HU GDF10 Antibody, FITC conjugated
Biotin CSB-PA009343LD01HU GDF10 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, WB, IHC
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Description

The rabbit anti-human GDF10 polyclonal antibody is an IgG antibody produced in rabbits that specifically recognizes and binds to the human and rat GDF10 protein. Its immunogen is the recombinant human GDF10 protein (369-478aa). Protein G purification of this GDF10 antibody brought it a purity of up to 95%. The specificity and reliability of this GDF10 antibody have been verified in ELISA, WB, and IHC applications.

GDF10 plays a crucial role in the regulation of cell growth, differentiation, and development in various tissues and organs. It especially promotes cell differentiation in the skeletal and nervous systems. It is also involved in the development and maintenance of bone and cartilage, as well as in the formation and repair of neural tissue.

Citations

Customer Reviews and Q&A

 Customer Reviews
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Applications : WB

Sample dilution: 1: 1000

Review: Western blots and quantification of ATRX, GDF10 and Lingo1 expression levels in the DCN of the tinnitus and non‑tinnitus groups and the control group are presented. GDF10 levels increased significantly at 3 weeks after noise exposure in the tinnitus group. data are presented as the mean ± SEM, as determined by one-way ANOVA followed by Tukey's post-hoc test.

By Anonymous

Target Background

Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Gene References into Functions
  1. Study shows that GDF10 is down-regulated in patients with oral squamous cell carcinoma, and is an independent risk factor for overall survival. Its expression is regulated by TGFBR3 which shares the signaling inhibiting epithelial-mesenchymal transition. PMID: 25728212
  2. GDF10 is a stroke-induced signal for axonal sprouting and functional recovery. PMID: 26502261
  3. new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha PMID: 18077449
  4. BMP3b and BMP6 genes were suppressed by DNA methylation and methylation of BMP3b is significantly frequent in Japanese malignant pleural mesotheliomas (MPMs), suggesting its pathogenic role and the ethnic difference in MPMs. PMID: 18949431
Subcellular Location
Secreted.
Protein Families
TGF-beta family
Tissue Specificity
Expressed in femur, brain, lung, skeletal muscle, pancreas and testis.
Database Links

HGNC: 4215

OMIM: 601361

KEGG: hsa:2662

STRING: 9606.ENSP00000224605

UniGene: Hs.2171

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