Human C-C motif chemokine 16(CCL16) ELISA kit

Code CSB-EL004779HU
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
20% off above 2 kits (96T) per item
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* Sample kit cost can be deducted as a $30 credit for each 96-assay kit of the same analyte and brand you subsequently purchase in six months till depleted. Apply now

Product Details

Target Name
chemokine (C-C motif) ligand 16
Alternative Names
C-C motif chemokine 16 ELISA Kit; CCL16 ELISA Kit; CCL16_HUMAN ELISA Kit; Chemokine (C-C motif) ligand 16 ELISA Kit; Chemokine CC-4 ELISA Kit; Chemokine LEC ELISA Kit; CKb12 ELISA Kit; HCC-4 ELISA Kit; HCC4 ELISA Kit; IL-10-inducible chemokine ELISA Kit; IL10 inducible chemokine ELISA Kit; IL10 inducible chemokine ELISA Kit; ILINCK ELISA Kit; LCC-1 ELISA Kit; LCC1 ELISA Kit; Liver CC chemokine 1 precursor ELISA Kit; Liver expressed chemokine ELISA Kit; Liver-expressed chemokine ELISA Kit; LMC ELISA Kit; Lymphocyte and monocyte chemoattractant ELISA Kit; Monotactin 1 ELISA Kit; Monotactin-1 ELISA Kit; MTN-1 ELISA Kit; Mtn1 ELISA Kit; NCC-4 ELISA Kit; NCC4 ELISA Kit; New CC chemokine 4 ELISA Kit; SCYA16 ELISA Kit; SCYL4 ELISA Kit; Small inducible cytokine A16 precursor ELISA Kit; Small inducible cytokine A16 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 16 ELISA Kit; Small-inducible cytokine A16 ELISA Kit
Uniprot No.
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
39.06 pg/mL-2500 pg/mL
9.77 pg/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This human CCL16 ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of human CCL16 in multiple samples, including serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the CCL16 levels in the sample and is measured at 450 nm through a microplate reader.

CCL16 is a chemokine predominantly expressed in the liver but is also found in the blood and brain. It plays important roles in immune response and angiogenesis. CCL16 specifically attracts lymphocytes, dendritic cells, and monocytes and increases their adhesive properties. CCL16 also possesses myelosuppressive activity. A study has shown that CCL16 binds explicitly to CCR2, which in turn activates the AKT/GSK3β signaling and promotes β-catenin nuclear translocation, leading to enhanced cancer cell stemness. CCL16 also leads to the migration of cancer cells if they express CCR1. On the other hand, CCL16 enhances the anti-cancer effects of cytotoxic T and dendritic cells (DC) lymphocytes.

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Target Background

(From Uniprot)
Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.
Gene References into Functions
  1. Overexpression of miR-1247 may alleviate LPS-induced A549 cell injury through targeting CCL16. PMID: 29768218
  2. Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma. PMID: 27357396
  3. High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. PMID: 22857868
  4. Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS. PMID: 21951809
  5. Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth PMID: 21288736
  6. Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity. PMID: 14525962
  7. An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice. PMID: 15034014
  8. CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils. PMID: 15265943
  9. CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response. PMID: 16226254
  10. Elevated concentrations in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia PMID: 19494526

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Subcellular Location
Protein Families
Intercrine beta (chemokine CC) family
Tissue Specificity
Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.
Database Links

HGNC: 10614

OMIM: 601394

KEGG: hsa:6360

STRING: 9606.ENSP00000293275

UniGene: Hs.10458

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