CCL16 Antibody

Datasheet

Code	CSB-PA08967A0Rb
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCL16 Polyclonal antibody

Uniprot No.

O15467

Target Names

CCL16

Alternative Names

C-C motif chemokine 16 antibody; CCL16 antibody; CCL16_HUMAN antibody; Chemokine (C-C motif) ligand 16 antibody; Chemokine CC-4 antibody; Chemokine LEC antibody; CKb12 antibody; HCC-4 antibody; HCC4 antibody; IL-10-inducible chemokine antibody; IL10 inducible chemokine antibody; IL10 inducible chemokine antibody; ILINCK antibody; LCC-1 antibody; LCC1 antibody; Liver CC chemokine 1 precursor antibody; Liver expressed chemokine antibody; Liver-expressed chemokine antibody; LMC antibody; Lymphocyte and monocyte chemoattractant antibody; Monotactin 1 antibody; Monotactin-1 antibody; MTN-1 antibody; Mtn1 antibody; NCC-4 antibody; NCC4 antibody; New CC chemokine 4 antibody; SCYA16 antibody; SCYL4 antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine A16 precursor antibody; Small inducible cytokine subfamily A (Cys Cys) member 16 antibody; Small-inducible cytokine A16 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C-C motif chemokine 16 protein (24-120AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCL16 Antibody (Product code: CSB-PA08967A0Rb) is Non-conjugated. For CCL16 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA08967B0Rb	CCL16 Antibody, HRP conjugated	ELISA
FITC	CSB-PA08967C0Rb	CCL16 Antibody, FITC conjugated
Biotin	CSB-PA08967D0Rb	CCL16 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

Gene References into Functions

Overexpression of miR-1247 may alleviate LPS-induced A549 cell injury through targeting CCL16. PMID: 29768218
Single nucleotide polymorphism (SNPs) located in and around the C-C motif chemokine ligand 16 (CCL16) gene are associated with CCL16 protein levels in blood plasma, and rs80329614 is the SNP most strongly associated with CCL16 protein levels in plasma. PMID: 27357396
High umbilical artery CCL16 is prominently detected in preterm preeclamptic pregnancies with severe growth restriction. PMID: 22857868
Data show that CCL-16 gene expression was upregulated by 7.46-fold in IBS patients when compared with controls and suggest a subclinical inflammatory component underlying IBS. PMID: 21951809
Low umbilical cord blood chemokine CCL16 associates with spontaneous preterm birth PMID: 21288736
Recombinant CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity. PMID: 14525962
An adenoviral vector encoding human CCL16 injected into mice with pre-established mammary carcinoma induces strong antitumor response; when given before surgical excision of primary lesions, the treatment prevents metastatic spread and cures 63% of mice. PMID: 15034014
CCL16 induced efficient migratory responses in human and mouse eosinophils. CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils. PMID: 15265943
CC chemokine-4 (HCC-4)/CCL16 transduces signals differently from other CCR1-dependent chemokines and may play different roles in the immune response. PMID: 16226254
Elevated concentrations in bronchoalveolar lavage fluid from patients with eosinophilic pneumonia PMID: 19494526

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Subcellular Location

Secreted.

Protein Families

Intercrine beta (chemokine CC) family

Tissue Specificity

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma-activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Database Links

HGNC: 10614

OMIM: 601394

KEGG: hsa:6360

STRING: 9606.ENSP00000293275

UniGene: Hs.10458

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Related pathways

Chemokine signaling pathway

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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