Human monocyte chemotactic protein 4,MCP-4 ELISA kit

Code CSB-E09762h
Size 96T,5×96T,10×96T How to order?
Trial Size 24T ELISA kits trial application
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Product Details

Description

This Human CCL13 ELISA Kit was designed for the quantitative measurement of Human CCL13 protein in serum, plasma, cell culture supernates, urine. It is a Sandwich ELISA kit, its detection range is 31.25 pg/mL-2000 pg/mL and the sensitivity is 7.81 pg/mL.

Alternative Names C-C motif chemokine 13 ELISA Kit; CCL13 ELISA Kit; CCL13_HUMAN ELISA Kit; Chemokine (C C motif) ligand 13 ELISA Kit; CK beta 10 ELISA Kit; CK-beta-10 ELISA Kit; CKb10 ELISA Kit; MCP-4 ELISA Kit; MGC17134 ELISA Kit; Monocyte chemoattractant protein 4 ELISA Kit; Monocyte chemotactic protein 4 ELISA Kit; NCC 1 ELISA Kit; NCC-1 ELISA Kit; NCC1 ELISA Kit; New CC chemokine 1 ELISA Kit; SCYA13 ELISA Kit; SCYL1 ELISA Kit; short chain ELISA Kit; Small inducible cytokine A13 precursor ELISA Kit; Small inducible cytokine subfamily A (Cys Cys) member 13 ELISA Kit; Small-inducible cytokine A13 ELISA Kit
Abbreviation CCL13
Uniprot No. Q99616
Species Homo sapiens (Human)
Sample Types serum, plasma, tissue homogenates.
Detection Range 39 pg/ml-2500 pg/ml.
Sensitivity 9.75 pg/ml.
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Assay Principle quantitative
Measurement Sandwich
ELISA Data Analysis Watch ELISA data processing video & download Curve Expert if needed
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

Function
(From Uniprot)
Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens.
Gene References into Functions
  1. CCL13 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
  2. CCL13 levels in serum and synovial fluid may serve as a biomarker for the progression of osteoarthritis. PMID: 25654294
  3. CCL13 is an antimicrobial protein with bacteriocidal activity against E. coli. PMID: 12949249
  4. Data suggest that CCL13 binds to several chemokine receptors (CCR1, CCR2, and CCR3), allowing CCL13 to elicit different effects on target cells of immune system. CCL13 is involved in pathology of chronic inflammatory/autoimmune diseases. [REVIEW] PMID: 23846739
  5. MCP-4 and hsCRP may be the markers linking chronic inflammation in obesity and periodontal disease. PMID: 23375121
  6. E(2) has adverse effects on the pathogenesis of RA as a result of unregulated cell death, increased TNF-alpha-induced MMP-3 production, and CCL13 overproduction, subsequently resulting in the disease progression of RA. PMID: 22393877
  7. Findings suggest that the pro-atherogenic effects of CCR2 may not be restricted to interaction with MCP-1, but could also involve activation by MCP-4, being an inflammatory link between platelet and monocyte activation. PMID: 20139115
  8. Data suggest that the monocyte chemoattractant protein-4 core promoter YY-1 binding motif is functional, and modulates the transcriptional regulation of the MCP-4 gene. PMID: 12805085
  9. The study was undertaken to understand the relationship between the functional proteomics of receptor-Ck and developmental stages of human atherosclerotic aortic wall. PMID: 14560935
  10. MCP-4 may be a critical molecule that links obesity and chronic inflammation. PMID: 16855189
  11. The Th2 cytokine IL-4 preferentially stimulated MCP-4 expression. PMID: 17541284
  12. interferon-gamma with IL-1beta/TNF-alpha activates the production of CCL13 from chondrocytes in RA joints; secreted CCL13 enhances fibroblast-like synoviocyte proliferation by activating the extracellular signal-regulated MAP kinases cascade PMID: 17824960
  13. TLR2, 3, 4 and 5 ligands, but not TLR7/8 or 9 ligands, synergized with IL-4 to induce the production of MCP-4 in nasal polyp fibroblasts. PMID: 17851891
  14. CCL13 and HSPC159 mRNA expressions in PBMC are up-regulated specifically in MCNS patients during the nephrosis phase. PMID: 18219197
  15. Oncostatin M can strongly up-regulate the expression of CCL13, a chemokine recently identified in the synovial fluid of patients with rheumatoid arthritis. PMID: 19565514

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Subcellular Location Secreted.
Protein Families Intercrine beta (chemokine CC) family
Tissue Specificity Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells.
Database Links

HGNC: 10611

OMIM: 601391

KEGG: hsa:6357

STRING: 9606.ENSP00000225844

UniGene: Hs.414629

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