Mouse Interleukin 1α,IL-1α ELISA kit

Instructions
Code CSB-E04621m
Size 96T,5×96T,10×96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name interleukin 1, alpha
Alternative Names Il1aInterleukin-1 alpha ELISA Kit; IL-1 alpha ELISA Kit
Abbreviation IL1A
Uniprot No. P01582
Species Mus musculus (Mouse)
Sample Types serum, plasma, tissue homogenates
Detection Range 2.35 pg/ml - 150 pg/ml
Sensitivity 0.58 pg/ml
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Immunology
Assay Principle quantitative
Measurement Sandwich
Precision   
Linearity   
Recovery  
Typical Data    

Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

Target Data

Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Gene References into Functions
  1. Infection with Mycobacterium bovis results in increase in interleukin-1alpha, TGF-beta1, and MMP1 in multinucleated macrophages. PMID: 29504104
  2. Together, these data suggest that caspase-11/IL-1alpha pathway plays an important role in defending against Klebsiella pneumoniae by recruiting neutrophils in the early stage of infection. PMID: 28939441
  3. These data highlight an important interdependency between the potent pro-inflammatory cytokine IL1A and Fshr expression. PMID: 28337831
  4. Since neither IL-1alpha nor IL-1beta depletions completely rescued the phenotype, we believe that IL-1alpha and IL-1beta have a similar and probably complementary role in FHF progression PMID: 28953903
  5. These results suggested that Streptococcus pneuomoniae PLY induces the influx of calcium in Streptococcus pneumoniae-infected macrophages, followed by calpain activation and subsequent IL-1alpha maturation and secretion. PMID: 28630064
  6. In response to chemically induced colitis, this microbial landscape promoted the release of IL-1alpha, which acted as a critical driver of colitis and colitis-associated cancer. PMID: 27775548
  7. our results suggest that mature IL-1alpha induced by hS100A7 is via RAGE-p38 MAPK and calpain-1 pathway in keratinocyte and this mechanism may play an important role during psoriasis. PMID: 28060905
  8. Il-1 signaling pathway has a key role in abdominal aortic aneurysm formation in mouse model of Kawasaki disease. PMID: 26941015
  9. endothelial cells were identified as the primary cellular source of G-CSF during OPC, which responded to IL-1alpha that was released from keratinocytes in the infected tissue. PMID: 27632536
  10. Key aspects of IL-1alpha biology and regulation especially with regard to inflammation are reviewed. Review. PMID: 27434011
  11. data suggested that pINSd needs IL-1R1 for inflammatory cytokine induction. Mouse embryo fibroblast cells of IL-1R1-deficient mice further confirmed that pINSd promotes immune responses through IL-1R1 PMID: 27226621
  12. IL-1alpha signaling and DNA damage is important for triggering a sterile inflammatory cascade . PMID: 26439902
  13. As a dual function cytokine, IL-1alpha may contribute to the induction of CHOP intracellularly, while IL-1alpha released from necrotic cells accelerates steatohepatitis via induction of inflammatory cytokines by neighboring cells. PMID: 26022690
  14. These data demonstrate that DC and macrophages display distinct patterns of cytokine regulation, particularly with respect to IL-1, as a consequence of cell-type specific differences in the physicochemical properties of the P2X(7)R PMID: 26068648
  15. Data suggest the role of stromal cell IL-1alpha and IL-1beta in Kawasaki disease vasculitis model. PMID: 26515418
  16. IL-1alpha and IL-36alpha form a self-amplifying inflammatory loop in vivo that in patients with insufficient counter regulatory mechanisms may become hyper-engaged and/or chronic PMID: 26203636
  17. IL-1alpha-positive cells were identified in the epithelium in dextran sulfate sodium (DSS)-induced colitis. IL-1alpha was detected in the stool of colitic mice before IL-1beta. PMID: 25864926
  18. IL-1alpha acts as an alarmin essential for leukocyte recruitment and protective immunity against HSV-1 PMID: 25323745
  19. The aim of this study was to characterize the role of IL-1 in cellular responses of carbon nanotubes in cells from IL-1alpha/beta wild type (IL1-WT) mice. PMID: 25748835
  20. These findings do not support the previously suggested role of nuclear IL-1alpha in gene regulation of IL-1beta. PMID: 25748836
  21. the underlying mechanism by which AR influences AAA development is through IL-1alpha and transforming growth factor-beta1, and provides a potential new therapy to suppress/prevent AAA by targeting AR with ASC-J9. PMID: 26324502
  22. inhibition of this potentially important source of chronic inflammation in atherosclerosis requires blockade of interleukin-1alpha and not interleukin-1beta. PMID: 26139463
  23. The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. PMID: 25058342
  24. data suggest that central inhibition of IL-1alpha or Tox3 overexpression during the acute phase of a CNS insult may be an effective means for preventing the loss of neurological function PMID: 26224856
  25. Data (including date from studies in knockout mice) suggest that neutralization/deletion of Il1a reduces Il1b production and neutrophil infiltration in lung after inhalation exposure to silica nanoparticles. PMID: 25497724
  26. The controlled release of IL-1alpha could be a critical regulator during acute liver inflammation PMID: 25870999
  27. it appears the balance between TPO and IL-1alpha determines the MK cellular programming for thrombopoiesis in response to acute and chronic platelet needs. PMID: 25963822
  28. In acute lung injury, lipopolysaccharide induced alveolar macrophage necrosis via CD14 and the P2X7 receptor leading to interleukin-1alpha release. PMID: 25862090
  29. IL-1alpha induced the proliferation of CD11b(low) alveolar macrophages and differentiated these cells into CD11b(high) macrophages which perform critical phagocytic functions and organize granuloma. PMID: 25421226
  30. Data indicate that interleukin-1 cytokines IL-1alpha and IL-1beta are regulated by polyubiquitination and proteasomal degradation. PMID: 25371210
  31. IL-1 is a key mediator driving an innate immune response to inflammatory challenge in the mouse brain but is dispensable in extracerebral tissues including the lung and peritoneum. PMID: 25367678
  32. findings identify IL-1alpha as a crucial early danger signal triggering post-MI inflammation. PMID: 25505286
  33. Immune complexes inhibit IL-1 secretion and inflammasome activation. PMID: 25320279
  34. Selective deficiency of IL-1alpha in Kupffer cells reduces liver inflammation and expression of inflammatory cytokines, which may implicate Kupffer cell-derived IL-1alpha in steatohepatitis development. PMID: 24582082
  35. cigarette smoke-induced neutrophilia was dependent on IL-1alpha produced by alveolar macrophages and alveolar macrophages isolated from smoke-exposed mice were primed for excessive IL-1alpha production in response to bacterial ligands. PMID: 25092891
  36. tested the possible role of the proinflammatory cytokine IL-1 in the age-related exhaustion of ovarian reserve using IL-1alpha and IL-1beta-KO mice PMID: 25114230
  37. This study documents distinct roles for IL-1alpha and IL-1beta in the response to Pseudomonas aeruginosa infection as a function of the type 3 secretion system effectors produced by the infecting strain. PMID: 25069982
  38. necroptosis caused the processing and release of IL-1alpha, and this was independent of IL-1beta processing and release PMID: 24790078
  39. IL-1 induces systemic inflammation and augments Streptococcal pneumoniae infection, atherosclerosis, and ischemic brain injury via platelet activation and microvascular coagulation. PMID: 24644058
  40. IL-1alpha was not released upon inflammasome activation unless significant cell damage occurred. PMID: 23684408
  41. haematopoietic-derived IL-1 is a key driver of ischaemic brain injury. PMID: 23519030
  42. In severe S. aureus bacteraemia in mice, TNF-alpha, IL-1alpha, and KC are biomarkers predicting fatal outcome of infection. PMID: 23520553
  43. Our results establish IL-1alpha as a critical initiator of the inflammatory response to L. pneumophila PMID: 23686480
  44. discovery of a novel inflammatory circuit in which RIP1-mediated IL-1alpha secretion in response to deregulated SHP-1 activity triggers an inflammatory destructive disease that proceeds independently of inflammasomes and programmed necrosis PMID: 23708968
  45. Results suggest importance of IL-1R1/IL-1alpha to the recruitment and activation of dendritic cells in response to cigarette smoke exposure. PMID: 22992200
  46. ERalpha-regulated repression of TNFalpha and IL1alpha is important for lumen formation and maintenance. PMID: 22328525
  47. Allergic sensitization to HDM was abolished in vivo when IL-1alpha, GM-CSF, or IL-33 was neutralized. PMID: 22802353
  48. Autophagy has a potentially pivotal role to play in the induction and regulation of inflammatory responses by innate immune cells, largely driven by IL-1 and its consequential effects on IL-23 secretion. PMID: 22972933
  49. Vascular wall resident cells are the main targets for the pro-atherogenic effects of bone marrow-derived IL-1 through IL-1R1, partly by induction of adhesion and chemotactic molecules in endothelial cells. PMID: 22236482
  50. This study demonstrated here in in vivo experiments that IL-1 exacerbates the effects of SCI by accentuating the impact of the inflammatory responses. PMID: 22483094
  51. analysis of IL-1alpha/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice PMID: 22163019
  52. Nitrogen-containing-bisphosphonate-induced peritonitis caused an increase in IL-1alpha, preceding a rise in other proinflammatory cytokines. IL-1R, IL-1alpha, & IL-1beta were required for neutrophil recruitment. PMID: 22387558
  53. treatment regulated the differentiation of preadipocytes. IL-1alpha C-889T (rs1800587) is a functional polymorphism of IL-1alpha associated with obesity. IL-1alpha may have a critical function in the development of obesity PMID: 22216303
  54. Inflammasome-caspase-1-dependent release of IL-1alpha and IL-1beta was independent of caspase-1 catalytic activity, defining a mode of action for caspase-1. PMID: 22444631
  55. Data show that in mice, as early as 4 h after reperfusion following ischemia induced by occlusion of the middle cerebral artery, IL-1alpha, but not IL-1beta, is expressed by microglia-like cells in the ischemic hemisphere. PMID: 22206506
  56. chemokine MIP-1alpha may play an important role in modulating the transition from radiation pneumonitis to pulmonary fibrosis in vivo PMID: 21777484
  57. IL-1alpha gene expression in the spleen (ninefold) and liver (fourfold) along with IL-1RI (threefold spleen and fivefold liver) were maximal at hypothermia. PMID: 21828249
  58. nonphagocytosed endothelial apoptotic bodies are inflammatory, providing a vehicle for IL-1alpha PMID: 22143786
  59. Different subsets of myeloid cells are recruited following stimulation by cell-derived IL-1alpha (neutrophils) compared to stimulation by IL-1beta (macrophages), inducing a distinct and unique response to inflammation. PMID: 21930960
  60. demonstrate that IL-1beta directly binds IL-1alpha, thus identifying IL-1beta as a shuttle for another proinflammatory cytokine. These results have direct impact on selective treatment modalities of inflammatory diseases PMID: 22006336
  61. Mice deficient in IL-1alpha are protected against cisplatin-induced acute renal failure. PMID: 21716595
  62. Vitamin D(3) strongly upregulated IL-1alpha in adult mouse prostate progenitor/stem cells, which was required for the antiproliferative effect of vitamin D(3). PMID: 21653679
  63. The results suggest that IL-1alpha is the major mediator of the IL-1RI-dependent and protective innate immune responses to Mycobacterium tuberculosis in mice. PMID: 21093494
  64. it is IL-1alpha from bone marrow-derived cells that accelerates atherogenesis in apoE-deficient mice rather than constitutive IL-1alpha in vascular cells, possibly by increasing the inflammatory cytokine profile of macrophages. PMID: 21219852
  65. uncovered a complex sequential relationship involving unique contributions from the lipid mediator LTB(4), the cytokine IL-1, and CCR1 and CXCR2 chemokine ligands that are all absolutely required for effective neutrophil recruitment into the joint. PMID: 20727790
  66. The dissimilarity of responses to IL-1alpha and IL-1beta suggests that these isoforms activate different signaling pathways within the two osteoclast populations. PMID: 20108252
  67. platelet activation of brain endothelium via IL-1alpha is a critical step for the entry of white blood cells, major contributors to inflammation-mediated injury in the brain. PMID: 20200351
  68. Host bone marrow-derived cells are the key source of the IL-1alpha that is required for the inflammatory response of necrotic cells. PMID: 20220089
  69. Nuclear trafficking and differential release during necrosis vs. apoptosis demonstrate that inflammation by IL-1alpha is tightly controlled. PMID: 20133797
  70. These data showed that listeriolysin O-mediated cytoplasmic entry of Listeria monocytogenes could induce the activation of intracellular calcium signaling, which is essential for maturation and secretion of IL-1 alpha in macrophages. PMID: 20194588
  71. Studies suggest that apoptotic VSMCs intracellular IL-1 acts on the surrounding viable VSMCs inducing them to release IL-6 and MCP)-1, thus perpetuating a chronic inflammatory state. PMID: 19926874
  72. The patterns of sialylation on fibrosarcoma cell lines arising following 3-methylcholanthrene treatments of wild-type and IL-1alpha-deficient mice, were examined. PMID: 19430902
  73. IL-1 alpha, produced by mature Langerhans cells migrating into the lymph nodes, is required for contact-allergen-specific T cell activation during the sensitization phase of contact hypersensitivity. PMID: 11717188
  74. the PI 3-kinase/Akt and ERK signaling pathways in the promotion of osteoclast survival by IL-1alpha. PMID: 11754748
  75. Interleukin-1alpha up-regulation in vivo by a potent carcinogen 7,12-dimethylbenz(a)anthracene (DMBA) and control of DMBA-induced inflammatory responses. PMID: 11809690
  76. IL-1 alpha/beta may play important physiological and pathophysiological roles on biobehavioral activities PMID: 11871152
  77. In situ hybridization revealed IL-1alpha and IL-6 mRNA localization in normal, dormant and activated blastocysts and a differential expression was observed in relation to the exposure to progesterone and estrogen. PMID: 11883745
  78. the capacity of Sertoli cell cultures, from immature mice, to produce IL-1alpha, IL-1beta and IL-1 receptor antagonist (IL-1ra) under in vitro cultures and in the presence of testicular physiological and pathological factors PMID: 11988319
  79. results show that selective alterations in the IL-1 family of cytokines occur with aging and that defects in IL-1 signaling may contribute to the epidermal permeability barrier abnormality of aged skin PMID: 12102659
  80. The signal transduction pathways have been identified that are involved in the metabolic action of IL-1 alpha on glucose utilization in primary cultures of cortical astrocytes. PMID: 12112371
  81. Enhanced IL-1 alpha production in osteoblasts mediates vitamin D3-stimulated osteoclast formation in spleen-osteoblast cocultures. PMID: 12193704
  82. Leishmania major activates IL-1 alpha expression in macrophages through a MyD88-dependent pathway PMID: 12270723
  83. IL-1 is required for tumor invasiveness and angiogenesis PMID: 12598651
  84. Levels are higher in homogenates of testicular tissue from sexually immature than those from mature mice. PMID: 12799211
  85. Results describe the role of interleukin-1 and interleukin-1 alpha receptors in maintaining body weight. PMID: 12975454
  86. IL-1alpha precursor interacts via its N-terminal peptide (IL-1NTP) with histone acetyltransferases PMID: 14612453
  87. Tumor cell-associated IL-1 alpha potentiates the development of antitumor immune responses, which limit the growth of malignant fibrosarcoma. PMID: 14662844
  88. during E. coli pneumonia in mice, the lack of signaling from TNF-alpha and IL-1 decreases inflammation and preserves lung compliance. PMID: 14966082
  89. production of IL-1 in the brain is not necessarily required for febrile response PMID: 15271886
  90. elevated levels of IL-1alpha in the oral micro-environment can mediate all of the clinical features of periodontal disease PMID: 15381720
  91. Has critical role in regulating Th2 responses during gastrointestinal nematode infection. PMID: 15549727
  92. The present study has shown that PM10 particles may exert their pro-inflammatory effects by modulating intracellular calcium signalling in macrophages leading to expression of pro-inflammatory cytokines. PMID: 15613243
  93. hepatocytes can be stimulated directly to produce hepcidin message by the cytokines IL-6, IL-1alpha, and IL-1beta PMID: 15684062
  94. In the striatum, IL-1alpha-ir was also detected in a non-astrocytic perivascular component, with a distribution similar to GAP-43-ir. IL-1alpha could thus directly or indirectly influence striatal reorganization after MPTP. PMID: 15922486
  95. TNF-alpha and IL-1alpha expressions are increased by glycolic acid in murine epidermis PMID: 16026578
  96. IL-1alpha activates KC gene via NF-kappaB signaling in mouse granulosa cells. PMID: 16825293
  97. IL-1 and TNFalpha serve as equally important mediators of hapten-induced alteration of Langerhans cell behaviors. PMID: 17123788
  98. expression of IL-1alpha in cells other than the bone marrow plays a significant role in non-HDL cholesterol metabolism PMID: 17173923
  99. Constitutively expressed IL-1alpha is critical for numerous interferon-gamma activities. PMID: 17360358
  100. MSCs protect lung tissue from BLM-induced injury by blocking TNF-alpha and IL-1 PMID: 17569781

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Subcellular Location Secreted
Protein Families IL-1 family
Database Links

KEGG: mmu:16175

STRING: 10090.ENSMUSP00000028882

UniGene: Mm.15534

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