Recombinant Mouse Interleukin-1 alpha(Il1a) (Active)

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Code CSB-AP004721MO
Product Type Interleukin
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Uniprot No. P01582
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm Filtered 50 mM Tris-HCl, 0.2 M NaCl, pH 8.0
Alias Interleukin-1 Alpha; IL-1 Alpha; Il1a
Species Mus musculus (Mouse)
Biological_Activity The ED50 as determined in a cell proliferation assay using mouse D10S cells is less than 20 pg/mL.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Immunology
Source E.coli
Gene Names Il1a
Expression Region 115-270aa
Tag Info Tag-Free
Mol. Weight 18 kDa
Protein Description Full Length of Mature Protein
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Function Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.
Subcellular Location Secreted
Protein Families IL-1 family
Database Links

KEGG: mmu:16175

STRING: 10090.ENSMUSP00000028882

UniGene: Mm.15534

Pathway MAPK signaling pathway
Cellular senescence
Hematopoietic cell lineage
Osteoclast differentiation
AGE-RAGE signaling pathway in diabetic complications

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