Recombinant Human Fibroblast growth factor 17 protein (FGF17) (Active)

FGF17 plays a critical role in embryonic brain development and has been implicated in tumor proliferation signaling through FGFR pathways, making it a valuable tool for oncology and developmental biology research. This tag-free recombinant human FGF17, covering the full mature sequence (residues 23–216), demonstrates strong mitogenic potency with an ED50 below 10 ng/mL in Balb/c 3T3 proliferation assays, corresponding to a specific activity exceeding 1.0 × 10⁵ IU/mg — performance that supports use in cell proliferation and survival assays, receptor-ligand binding studies via SPR or ELISA, and in vivo tumor biology models. The E. coli expression system produces a non-glycosylated protein, which provides a defined baseline free of glycan variability for quantitative receptor-binding competition experiments and antibody characterization workflows. Purity exceeding 95% by SDS-PAGE combined with endotoxin levels below 1.0 EU/μg satisfies the criteria typical for cell-based angiogenesis assays and neuronal differentiation studies.