Recombinant Human Interleukin-15(IL15),partial (Active) (GMP)

In StockGMP
Code CSB-AP005861HU
Product Type Interleukin
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Uniprot No. P40933
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Storage Buffer Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Alias IL-15
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 106 IU/mg.
Purity > 98 % by SDS-PAGE and HPLC analyses.
Endotoxin Less than 0.01 EU/μg of rHuIL-15 GMP as determined by LAL method.
Research Area Immunology
Source E.Coli
Gene Names IL15
Expression Region 49-162aa
Tag Info Tag-Free
Mol. Weight 12.9 kDa
Protein Description Partial
PubMed ID 8178155; 8932977; 8668345; 9405632; 14702039; 15489334; 21167836
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Function Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
Subcellular Location Isoform IL15-S48AA: Secreted, SUBCELLULAR LOCATION: Isoform IL15-S21AA: Cytoplasm, Nucleus
Protein Families IL-15/IL-21 family
Tissue Specificity Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Database Links

HGNC: 5977

OMIM: 600554

KEGG: hsa:3600

STRING: 9606.ENSP00000296545

UniGene: Hs.168132

Pathway Jak-STAT signaling pathway
TNF signaling pathway

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