Recombinant Human Interleukin-9 protein(IL9) (Active)

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Code CSB-AP001781HU
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Product Details

Purity >95% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human MO7e cells is less than 0.2 ng/ml, corresponding to a specific activity of >5.0x106 IU/mg.
Target Names IL9
Uniprot No. P15248
Research Area Immunology
Alternative Names Cytokine P40; Homolog of mouse T cell and mast cell growth factor 40; HP40; IL 9; IL-9; Il9; IL9_HUMAN; Interleukin 9; Interleukin-9; Mast cell growth factor; MCGF; Megakaryoblast growth factor; P40; p40 cytokine; p40 T cell and mast cell growth factor ; T cell growth factor 3 ; T cell growth factor p40 ; T-cell growth factor P40; TCGF 3
Species Homo sapiens (Human)
Source E.coli
Expression Region 19-144aa
Complete Sequence QGCPTLAGIL DINFLINKMQ EDPASKCHCS ANVTSCLCLG IPSDNCTRPC FSERLSQMTN TTMQTRYPLI FSRVKKSVEV LKNNKCPYFS CEQPCNQTTA GNALTFLKSL LEIFQKEKMR GMRGKI
Mol. Weight 14.1 kDa
Protein Length Full Length of Mature Protein
Tag Info Tag-Free
Form Lyophilized powder
Buffer Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Supports IL-2 independent and IL-4 independent growth of helper T-cells.
Gene References into Functions
  1. this study shows that intensified IL-9 production is associated with the immunopathogenesis of active ulcerative colitis PMID: 29927662
  2. IL9 CNS-25/IL9 CNS-18 is a critical and conserved regulatory element for IL-9 production in mice and humans. PMID: 30442929
  3. CXCL10, not CXCL9 or CXCL11, induced IL-9 expression in the liver tissue. PMID: 29860220
  4. Our study reveals that degeneration and destruction of cartilage may be related to the production of IL-9 in osteonecrosis of the femoral head patients. In a human primary chondrocytes culture model, IL-9 increased the degeneration of cartilage; blocking JAK-STAT signaling alleviated this effect. PMID: 29775946
  5. Having one or more copies of the 1635A allele was associated with increased cytomegalovirus acquisition in HIV-infected infants (42 vs. 11%, P = 0.03) and increased risk of Epstein-Barr virus acquisition in HIV-exposed uninfected infants (hazard ratio = 4.2, P = 0.02) compared with 1635GG. PMID: 29112074
  6. T Helper 9 cells may be the major source of interleukin-9 (IL-9) in children with allergic asthma. In these patients, IL-9 impairs interferon gamma production and synergistically promotes interleukin-4-induced IgE secretion. PMID: 28724400
  7. Increased expression of nuclear factor of activated T cells 1 drives IL-9-mediated allergic asthma. PMID: 26993036
  8. these results demonstrated that IL-9-expressing Th9 cells were upregulated in breast cancer patients and potentially possessed antitumor roles by enhancing CD8+ T cell-mediated cytotoxicity PMID: 28918288
  9. Serum IL-9 and IL-22 are associated with eosinophilia in cow's milk allergy, and decrease in these two cytokines with occurs with cow's milk elimination. PMID: 28934137
  10. The systemic IL9 level is higher in ulcerative colitis and corresponds with endoscopic inflammation, suggesting its possible application as a negative marker of mucosal healing. PMID: 28652656
  11. These findings suggest that IL-9 is involved in the pathogenesis of VKH disease, and that IL-9 might also enhance the inflammatory response by increasing the secretion of IL-17, an established proinflammatory cytokine in VKH disease PMID: 28761327
  12. Data suggest that the conditions defined for strong induction of interleukin-9 (IL-9) might be relevant for the development of Vdelta2 T-cell-based immunotherapy. IL-9 might be relevant for the development of Vdelta2 T-cell-based immunotherapy. PMID: 27791087
  13. An aberrant expression profile of Th9/IL-9 was associated with pathogenesis of immune thrombocytopenia, possibly through cooperative interaction with Th17/IL-17. PMID: 27662073
  14. In vitro data indicate that IL9 is regulated by STAT3/5 and in vivo results highlight the pro-neoplastic effect of IL9 on lymphoma T cells. The results suggest that IL9 and its regulators are promising new targets for therapy development in mycosis fungoides. PMID: 26851186
  15. recent findings suggest that blockade of IL-9 signaling is effective in treating experimental models of autoimmune and chronic inflammatory diseases such as inflammatory bowel diseases, allergic disorders such as food allergy and asthma. PMID: 26976761
  16. Findings showed that serum levels of IL-9 were elevated in diffuse large-B-cell lymphoma (DLBCL) patients and positive expression of IL-9 was correlated with adverse prognosis indicators. It directly effected proliferation and apoptosis of DLBCL cells by enhancing the expression of p21CIP1 genes and promoted tumor cells to display resistance to chemotherapeutic drugs. PMID: 27364124
  17. no differences were found in serum levels of IL-9 between different clinical forms of periportal fibrosis in human Schistosoma mansoni infection in Brazil PMID: 27506138
  18. PU.1 and IL-9 may play a role in AD pathogenesis and relate to disease severity and clinical eruption types. PMID: 28229452
  19. Inflammatory cell expression of IL-9 and IL-17C were increased in chronic rhinosinusitis, particularly with allergy and asthma. These interleukins may contribute to the pathogenesis of chronic rhinosinusitis with nasal polyps as well as atopy and may serve as therapeutic targets for disease management PMID: 26989880
  20. serum levels determined of both T cell polarizing (IL- 33 and IL-12) and T cell effector (IFN-gamma, IL-4, IL-10, IL-17 and IL-9) cytokines in T1DM (type-1 Diabetes Mellitus) subjects with and without microvascular complications (MVC). All the tested cytokines were significantly elevated in T1DM subjects except for IFN-gamma with no significant difference between those with and without MVC. PMID: 27442004
  21. results suggest that Th9 cells and IL-9 could play an important role in the pathogenesis of systemic sclerosis by modulating adaptive and innate immune responses and the production of autoantibodies and indicate the IL-9 pathway as a possible therapeutic target PMID: 28681919
  22. TL1A differentially induces expression of TH17 effector cytokines IL-17, -9, and -22 and provides a potential target for therapeutic intervention in TH17-driven chronic inflammatory diseases. PMID: 27733581
  23. These data indicate that IL-9 is an essential regulator of megakaryopoiesis and a promising therapeutic agent for treatment of thrombocytopenia such as CIT. PMID: 28450306
  24. Expression of IL-9 remarkably increases in peripheral blood and liver tissues in patients with primary biliary cirrhosis PMID: 27916102
  25. IL-9 promotes proliferation and metastasis in pancreatic cancer cells; this effect may partly involve regulation of the miR-200a/b-catenin axis. PMID: 28349057
  26. in PsA patients gammadelta T cells activation is driven prevalently by IL-9/IL-9R interaction, and not only by IL-23/IL-23R. Together these findings indicate gammadelta T cells and IL-9 as new players in the pathogenesis of PsA. PMID: 27543964
  27. Th9 cells produce IL9 that may participate in pathogenesis of Takayasu's arteritis PMID: 27629397
  28. IL-9 serum leves are elevated in patients with systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis but their clinical significance is unknown. [review] PMID: 26921642
  29. Th9 cell numbers and IL-9 levels are correlated with OA patient symptoms and joint functionality PMID: 26926842
  30. IL-9 is functionally active, and is a pro-growth/survival factor for the localized pathologic T cells in the synovium of inflammatory arthritis. PMID: 26751012
  31. Asthmatic children showed an increase in plasma Il9 levels post Mycoplasma pneumoniae infection. PMID: 26191227
  32. Interleukin-9 Is Associated with Elevated Anti-Double-Stranded DNA Antibodies in Lupus-Prone Mice PMID: 25902303
  33. Data demonstrated increased serum levels of IL-9 in systemic lupus erythematosus and rheumatoid arthritis patients but no association with clinical and laboratory parameters was found. PMID: 26078482
  34. identified as a gene target that might interact with environmental exposure to dust mite allergen to increase asthma severity in children PMID: 25913104
  35. association between IL-9 and diabetic kidney disease was complex as it was reduced in diabetes mellitus, but it was of normal levels in those with diabetic kidney disease PMID: 25542095
  36. secretion increased in respiratory epithelial adenomatoid hamartoma tissue PMID: 26131817
  37. The results provide evidence that IL-9 is predominantly involved in the pathogenesis of ulcerative colitis suggesting that targeting IL-9 might become a therapeutic option for patients with UC. PMID: 24957265
  38. Serum IL-9 is closely related to several clinical features, such as age, B symptoms and local lymph node involvement. It can also be an independent prognostic factor for extranodal NK/T-cell lymphoma, which suggests a role for IL-9 in disease pathogenesis PMID: 24722378
  39. Upregulation of IL-9 induced by pSTAT6 may be involved in the pathogenesis of chronic lymphocytic leukemia. PMID: 24966942
  40. IL-9 is a key component of memory TH cell peanut-specific responses from children with peanut allergy (PA) and may be a useful biomarker to distinguish between children with PA and those with peanut sensitization. PMID: 25112699
  41. Overexpression of IL-9 may contribute to the pathogenesis of chronic lymphocytic leukemia and is associated with some adverse prognostic parameters. PMID: 24551294
  42. This study demonstrates that IL-9, through its direct effects on Th1 and ability to promote IL-4 secretion, has a regulatory role for Th1 lymphocytes in allergic contact dermatitis. PMID: 24487305
  43. A role for the IL-9/IL-9R axis in the atherosclerotic process, is reported. PMID: 24023645
  44. IL-9 production by memory T-helper (TH)9 cells is higher in the peripheral blood of patients with asthma than in healthy donors. PMID: 24468256
  45. Recruitment of interleukin 9-producing CD4+ T cells into malignant pleural effusion could be induced by pleural CCL20 and that the majority of Th9 cells in MPE displayed the phenotype of effector memory cells. PMID: 23700286
  46. The activator protein 1 (AP1) family transcription factor BATF (B cell, activating transcription factor-like) was among the genes enriched in Th9 cells and was required for the expression of IL-9 and other Th9-associated genes. PMID: 24216482
  47. the expansion of the Th9 cell subset, up-regulation of the PU.1 transcription factor and increased secretion of the IL-9 cytokine may contribute to the pathogenesis of AD PMID: 24032555
  48. Higher numbers of TH9 cells occur in normal human skin & blood vs metastatic lesions of progressive stage IV melanoma. These results suggest a role for IL-9 in tumor immunity. PMID: 22772464
  49. Children with atopic dermatitis may have higher serum IL-9 levels than healthy children, and IL-9 levels are significantly related to symptom severity. PMID: 22612419
  50. Substantial renal IL-9 release was observed from deceased donor kidneys PMID: 22971662
  51. Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP. PMID: 23376058
  52. Results suggest a lack of participation of IL-9 in human liver allograft rejection. PMID: 22841205
  53. Results indicated that increased serum IL-9 concentrations accompanied a lower immunosuppressive load in liver transplant recipients. PMID: 22841206
  54. IL-9 contributes to disease by promoting mast cell expansion and production of IL-13 which in turn contributes to airway hyperresponsiveness. PMID: 23034251
  55. contributes to immunosuppression mediated by regulatory T cells and mast cells in B-cell non-hodgkin's lymphoma PMID: 21898141
  56. Serum IL-9 level was increased in patients with systemic sclerosis, and was associated with lower frequency and severity of pulmonary fibrosis in systemic sclerosis. PMID: 21807780
  57. IL-33 can initiate IL-9 protein secretion in vitro in human CD4+ T cells and basophils. PMID: 21765905
  58. TAK1-c-Rel and IRF4 pathways play distinct roles in the maintenance of IL-9-producing Th17 phenotype of HTLV-1-transformed cells PMID: 21498517
  59. analysis of IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population PMID: 21371865
  60. results demonstrate a previously unappreciated role for IL-9 in dampening the pathogenic activities of Th17 cells PMID: 21360526
  61. Serum IL-9 levels may depend on allergen exposure: symptomatic patients with pollen-induced allergic rhinitis (AR), evaluated during the pollen season, have higher values than patients studied outside the pollen season and without symptoms. PMID: 20861646
  62. the IL-9 genetic polymorphism (rs2069885) has an opposite effect on the risk of severe respiratory syncytial virus bronchiolitis in boys and girls. PMID: 20503287
  63. data clearly demonstrate the central function of interferon regulatory factor 4 in the development of T helper 9 cells and underline the contribution of this T helper cell subset to the pathogenesis of asthma. PMID: 20674401
  64. After initial differentiation of naive cells, IL-9 expression by human T helper type (Th)17 cells is acquired as a late event, suggesting that IL-9 and IL-17 can, in fact, be coexpressed by the same cell in humans. PMID: 20498357
  65. Investigation of IL-9-producing CD4(+)T cells, and elucidation of the mechanisms of IL-9-induced STATs signaling, in concert with other transcription factors, will provide a better understanding of the pathogenesis of various autoimmune diseases--REVIEW PMID: 20020328
  66. serum levels are associated with severity of rhinorrhea in allergic rhinitis patients PMID: 20306823
  67. These studies indicate differential involvement of the IL-9/IL-9R pathway in systemic and oral antigen-induced anaphylaxis. PMID: 20159257
  68. HCLCA1 is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma PMID: 11842292
  69. IL-9 inhibition of oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated monocytes involves the potentiation of TGF-beta 1 production and extracellular signal-regulated kinase inhibition. PMID: 11937570
  70. IL-9 can potentiate human megakaryocytopoiesis in the presence of Epo and/or SCF PMID: 12482498
  71. airway smooth muscle is a target for IL-9 and that IL-9 amplifies the potential for these cells to recruit eosinophils and neutrophils into the airways by a mechanism involving ERK. PMID: 12588703
  72. IL-9 induced goblet cell hyperplasia during repair of human airway epithelia. PMID: 12594054
  73. IL-9 appears to act as a potent enhancer for the SCF-dependent growth of mast cell progenitors in humans, particularly asthmatic patients. PMID: 12646606
  74. Segmental allergen challenge in patients with atopic asthma leads to increased IL-9 expression in bronchoalveolar lavage fluid lymphocytes. PMID: 12789235
  75. expression of IL-9 protein and mRNA in bronchi of patients with nasal polyposis PMID: 15007348
  76. Genetic cross of IL-9-transgenic mice with X-linked immunodeficient (xid) mice generates xid mice that have normal B-1 cell numbers because of a specific expansion of CD5-negative B-1b cells. PMID: 15128795
  77. Induction of IL-9 is associated with pathogenesis of EBV-associated T-cell diseases PMID: 15289339
  78. IL-9 and its receptor have roles in cell growth and malignant transformation of lymphoid cells associated with constitutive activation of the Jak/STAT pathway [review] PMID: 15621723
  79. Neutralization of IL-9, a susceptible factor in BALB/c mice with Leishmania major infection, results in a reduction of detrimental T helper (Th) cell type 2 responses with an observed shift toward protective Th1/type 1 immune responses. PMID: 15699153
  80. High interleukin-9 ;evelis asociated with nasal natural killer/T-cell lymphoma PMID: 16322282
  81. IL-9/Jak3 signaling plays a significant role in the pathogenesis of ALK+ anaplastic large-cell lymphoma PMID: 16763206
  82. Synthesis of IL-9, a Th2 cytokine, is dependent on IL-2, a Th1 cytokine, which is produced by Th cells themselves. PMID: 17541281
  83. increased expression of IL-9 may contribute to the development of tuberculosis PMID: 18032114
  84. primary ATL cells, via IL-9, support the action of IL-9Ralpha/CD14-expressing monocytes, which subsequently support the ex vivo spontaneous proliferation of malignant T cells PMID: 18339896
  85. House dust mite extract induces interleukin-9 expression in human eosinophils. PMID: 18349591
  86. Coincubation with IL-9 or IL-13 was protective against this corticosteroid-induced apoptosis by up-regulation of Bcl-2 PMID: 19005922
  87. Individuals carrying the A allele of the IL-9 promoter display increased synthesis of IL-9, which may result in strong Th2 immune responses and a modulation of their susceptibility to infectious, neoplastic, parasitic or atopic disease. PMID: 19387455
  88. IL9 single-nucleotide polymorphism is asociated with lung function and polysensitization. PMID: 19536153

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Subcellular Location Secreted
Protein Families IL-7/IL-9 family
Database Links

HGNC: 6029

OMIM: 146931

KEGG: hsa:3578

STRING: 9606.ENSP00000274520

UniGene: Hs.960

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