SSB Monoclonal Antibody

1. A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA. PMID: 28782243
2. our data support a novel model, whereby cancer-associated La protein contributes to cisplatin resistance by stimulating the translation of anti-apoptotic factor Bcl2 in HNSCC cells. PMID: 27105491
3. La protein is an important microprocessor component regulating miRNA processing efficiency by association with DGCR8 to regulate formation of the DGCR8-Drosha complex for miRNA processing. PMID: 29087193
4. La functions as gatekeeper ensuring correct tRNA maturation and protecting the miRNA pathway from potentially functional tRNA fragments. PMID: 27345152
5. Findings identified two novel SUMO acceptors sites on La and suggest that sumoylation of La alters its RNA-binding activity, which could influence a broad range of RNA processing steps where La's function has been implicated. PMID: 27224031
6. Binding of double-stranded RNA involves less penetration into the RNA recognition motif (RRM2) binding pocket and more engagement with the unstructured C-terminus of the La C-terminal domain (CTD). PMID: 27959512
7. At the 3' UTR, HUR facilitates circularization of the viral genome through interaction with another host factor, La, which is critical for replication. PMID: 26339049
8. expression of nuclear hLa Ag induces thymic clonal deletion and tTreg selection, and lymphocytic infiltration of the lung is a consequence of La-specific CD4(+) T cell autoimmunity PMID: 25582858
9. Authors provide a model whereby a novel interplay between RNA-binding, RNA chaperoning and AKT phosphorylation of La protein regulates CCND1 IRES-mediated translation. PMID: 25520193
10. Primary Sjogren's patients with WSP form a benign subgroup, with a lower prevalence of anti-SSB and extraglandular manifestations. PMID: 24529195
11. A beta turn in the human La protein is responsible for the interaction with the hepatitis C virus RNA. PMID: 24478427
12. Total IgG levels correlate positively with autoantibodies La, Ro60 and Ro52 but not with RING or B-box domain antibodies of Ro52. PMID: 23554036
13. The competition between the host factor (La) and the viral protein (NS3) for binding to HCV IRES might regulate the molecular switch from translation to replication of HCV. PMID: 22355520
14. Our study demonstrates that La plays a critical role in regulating HCV replication by interacting with the GCAC motif. PMID: 23552417
15. Sjogren syndrome antigen B (SSB)/La promotes global microRNA expression by binding microRNA precursors through stem-loop recognition PMID: 23129761
16. Iron promotes the translation initiation of hepatitis C virus by stimulating the expression of eIF3A and La proteins. PMID: 22634302
17. oxidants cause nuclear export of La/SSB protein and subsequent association of La/SSB with Nrf2 untranslated regions and ribosomes PMID: 22207702
18. data indicate that the JAK2(V617F) mutation affects p53 response to DNA damage through the upregulation of La antigen and accumulation of MDM2 PMID: 21785463
19. the structural elements required for La-mediated RNA chaperone activity PMID: 22203678
20. La binds to domain IV of the hepatitis C virus RNA using an RNA recognition that is quite distinct from its mode of binding to RNAs with a 3' UUU(OH) trailer. PMID: 22009680
21. function of the RNA-binding protein La in promoting tumor progression of head and neck squamous cell carcinoma PMID: 22016766
22. Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RNA-induced silencing complex catalysis. PMID: 22055194
23. Overexpression of mouse or human La enhanced M-MuLV particle release in the absence of glycosylated gag. PMID: 21343359
24. La protein binds to and mediates interaction of the 5' and 3' noncoding ends of the Japanese encephalitis virus genome. PMID: 21294637
25. show elevated La protein expression in cervical cancer tissue and its correlation with aberrant CCND1 protein levels in cervical tumor tissue lysates PMID: 20856207
26. There is a correlation between La protein and HBV mRNA and the expression of HBV protein. PMID: 17064465
27. study found expression of La protein is induced by HCV infection, and this induced La protein-activated telomerase activity in a hepatoma cell line; HCV infection might be strongly related to telomerase activity in the liver through La protein induction PMID: 20497049
28. nuclear trafficking by La affects the normal order of pre-tRNA processing PMID: 12049746
29. molecular characterization of the human La protein.hepatitis B virus RNA.B interaction in vitro PMID: 12121976
30. La autoantigen is required for the internal ribosome entry site-mediated translation of Coxsackievirus B3 RNA PMID: 12384597
31. binds differentially to multiple sites within the 5' untranslated region of Coxsackievirus B3 RNA PMID: 12457960
32. in addition to full-length La protein, both N- and C-terminal halves were able to interact with hepatitis C virus internal ribosome entry site in vivo. PMID: 12540850
33. Dengue 4 virus minus strand 3'UTR RNA binds with La protein in human monocytes PMID: 12584332
34. Results suggest that La ribonucleoproteins (RNP) exist in distinct states that differ in subcellular localization, serine 366 phosphorylation, and associated RNAs. PMID: 14636586
35. La motif adopts an alpha/beta fold that comprises a winged-helix motif elaborated by the insertion of three helices PMID: 15004549
36. La protein binds to the 5' end and with the 3' UTR of Dengue virus RNA; interacts with the dengue virus nonstructural proteins NS5 and NS3 PMID: 15084396
37. NMR assignment and secondary structure of the La motif PMID: 15213463
38. Composition of La/hepatitis B virus ribonucleoprotein particles as well as interacting cellular factors, are critical determinants in the regulation of the stability of the HBV RNA. PMID: 15302879
39. RRM1 and La motifs bind pre-tRNA PMID: 15371415
40. CK2 is responsible for La S(366) phosphorylation in vivo PMID: 15485924
41. Nonphosphorylated SSB interacts with nucleolin at nucleolar sites involved in rRNA biogenesis. PMID: 15572691
42. This protein is s host factors responsible for the regulation of the hepatitis C virus internal ribosome entry site. PMID: 15685555
43. essential for efficient hepatitis C virus replication PMID: 15823607
44. In vitro RNA chaperone activity pf SSB was studied. PMID: 15928345
45. nuclear retention of peptidylglycine alpha-amidating monooxygenase (PAM) mRNA is lost upon expressing the La proteins that lack a conserved nuclear retention element, suggesting a direct association between PAM mRNA and La protein in vivo PMID: 16107699
46. Anti-La antibodies bound to immunodominant epitopes of La within the NH(2)-terminus and the RNA recognition motif (RRM) region of apoptotic human cells PMID: 16320341
47. Here, we show by chromatin immunoprecipitation (ChIP) that La is associated with pol III-transcribed genes in vivo PMID: 16344466
48. Results report the crystal structure of the N-terminal domain of human La, consisting of La and RRM1 motifs, bound to RNA. PMID: 16387655
49. Changes in salivary production rate are associated with aging and SSB antibodies. PMID: 16467037
50. La protein undergoes nucleocytoplasmic shuttling whereas EBER1 and EBER2 noncoding RNA's are confined to the nucleus. PMID: 16682524

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HGNC: 11316

OMIM: 109090

KEGG: hsa:6741

STRING: 9606.ENSP00000260956

UniGene: Hs.632535