TUBB1 Monoclonal Antibody

Code CSB-MA000278
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Western blot analysis of Zebrafish skeletal muscle, diluted at 1:5000.

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Product Details

Uniprot No. Q9H4B7
Target Names TUBB1
Alternative Names 2810484G07Rik antibody; beta 1 tubulin antibody; Beta tubulin 1, class VI antibody; Beta-tubulin antibody; Class VI beta tubulin antibody; dJ543J19.4 antibody; M(beta)1 antibody; TBB1_HUMAN antibody; TUBB1 antibody; Tubulin beta 1 class VI antibody; Tubulin beta-1 chain antibody; Tubulin, beta 1 antibody; tubulin, beta1 antibody
Raised in Mouse
Species Reactivity Zebrafish
Immunogen Synthetic Peptide
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Form Liquid
Tested Applications ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Gene References into Functions
  1. Neonatal platelets exhibit low levels of the Stx11-Munc18b complex (essential component of the SNARE machinery) and of beta1-tubulin. These developmental deficiencies are associated with defects in platelet adhesion, spreading and secretion. PMID: 29044293
  2. novel DCX mutation (p.D90G, NP_000546.2) appeared to be a major causative variant, whereas the novel mutation of TUBB1 (p.R62fsX, NP_110400.1) was found only in patients with more-severe intellectual disability in Familial pachygyria PMID: 26743950
  3. Analysis of the TUBB1 gene revealed three known missense variants in heterozygous state which in combination might explain the beta1-tubulin defect. PMID: 26540125
  4. TUBB1 R307H SNP is significantly associated with the degree of thrombocytopenia in congenital and acquired platelet disorders, and may affect platelets by altering microtubule behavior. PMID: 25529050
  5. Data indicate that ABCB1 protein, beta tubulin I and III (betaI, and betaIII tubulin) might contribute to the multidrug resistance (MDR) of MCF7/DOC and be potential therapeutic targets for overcoming MDR of breast cancer. PMID: 24894670
  6. TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia. PMID: 24344610
  7. our findings define beta-tubulin VI as a hematologic isotype with significant genetic variation in humans that may affect the myelosuppresive action of microtubule-binding drugs PMID: 22805305
  8. homozygous status of P43 genetic polymorphism causes alterations in platelet ultrastructure PMID: 21384078
  9. Studies show that BFBTS bound and modified beta-tubulin at residue Cys12, forming beta-tubulin-SS-fluorobenzyl. PMID: 19996274
  10. SLPI localizes in part along the megakaaryocyte and platelet cytoskeleton by virtue of specific interactions with beta1 tubulin. PMID: 15315966
  11. the platelet Q43P beta1-tubulin substitution is frequent in the healthy population and may protect men against arterial thrombosis PMID: 15956286
  12. The TUBB1 Q43P polymorphism, by causing a lower reactivity in platelets carrying the variant form of b1-tubulin, protects against thrombotic disorders but increases the risk of intracerebral hemorrhage in men. PMID: 17488662
  13. biophysical analysis of carboxy-terminal tail conformation of human beta-tubulin isotypes PMID: 17993481
  14. Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly. PMID: 18849486
  15. TUBB1 Q43P polymorphism does not protect against acute coronary syndrome and premature myocardial infarction. PMID: 19132255

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Involvement in disease Macrothrombocytopenia, autosomal dominant, TUBB1-related (MAD-TUBB1)
Subcellular Location Cytoplasm, cytoskeleton
Protein Families Tubulin family
Tissue Specificity Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.
Database Links

HGNC: 16257

OMIM: 612901

KEGG: hsa:81027

STRING: 9606.ENSP00000217133

UniGene: Hs.303023

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