Timp1 Monoclonal Antibody

Datasheet
Code CSB-MA167191A0m
Product Type Monoclonal Antibody
Size US$350Purchase it in Cusabio online store
(Shop online in the US. Customers outside the US,
please order from local distributors.)
Uniprot No. P30120
Image
  • Immunohistochemistry of paraffin-embedded Rat prostate cancer using CSB-MA167191A0m at dilution of 1:100.

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Rat Timp1
Raised in mouse
Species Reactivity Rat
Specificity specific for Rat Timp1 denatured and native forms
Tested Applications ELISA,IHC;Recommended dilution:IHC:1:50-1:500
Relevance Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Form liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method >95%,Protein G purified
Isotype IgG1
Clonality monoclonal
Alias Timp-1
Immunogen Species Rattus norvegicus (Rat)
Gene Names Timp1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Clone No. 4A2B1
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Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity.
Subcellular Location Secreted
Protein Families Protease inhibitor I35 (TIMP) family
Database Links

KEGG: rno:116510

STRING: 10116.ENSRNOP00000013745

UniGene: Rn.25754

Pathway HIF-1 signaling pathway

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