Code | CSB-MP012365HU1 |
MSDS | |
Size | $396 |
Order now | |
Image |
|
Have Questions? | Leave a Message or Start an on-line Chat |
Recombinant human KIR3DL2 protein is produced using a mammalian cell expression system. The gene fragment encoding human KIR3DL2 (22-340aa) is fused with a 10xHis-tag gene at the C-terminus and inserted into a plasmid vector. The recombinant vector is transfected into mammalian cells, which are then cultured for protein expression. The harvested recombinant human KIR3DL2 protein exhibits over 90% purity as determined by SDS-PAGE, and its endotoxin content is less than 1.0 EU/ug measured by the LAL method. The protein's activity is validated through its interaction with KIR3DL2 recombinant antibody (CSB-RA012365MA1HU), showcasing its potential for research and clinical applications.
KIR3DL2 is not only expressed on NK cells, T cells, and B cells, but also on DC cells, monocytes, and macrophages. Both KIR and their ligand MHC-I molecules exhibit high polymorphism, and specific KIR-MHC-I interactions can influence the occurrence, progression, and outcomes of various diseases, such as pregnancy complications, viral infections, autoimmune diseases, and hematologic malignancies. MHC-I molecules are expressed on the majority of cells in the body, and the presence of inhibitory receptors KIR and KLR effectively prevents NK cells from attacking normal self-tissue cells. The anti-tumor activity of NK cells may be inhibited through monoclonal antibodies that block the KIR signaling pathway and disrupt its interaction. Research on therapeutic strategies based on KIR-HLA interactions will contribute to treatments for autoimmune diseases, cancer, and cytokine-related conditions. Consequently, some anti-KIR monoclonal antibodies have been applied in clinical trials. Developing active mammalian KIR3DL2 protein aids in creating monoclonal antibodies targeting inhibitory receptors, blocking inhibitory signaling pathways, and restoring NK cell functionality for treating malignant diseases.
There are currently no reviews for this product.