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| Code | CSB-CF856923HU |
| Product Type | Other |
| Size |
US$5078Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | Q96E52 |
| Relevance | Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. |
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| Storage Buffer | Tris-based buffer，50% glycerol |
| Alias | Metalloprotease-related protein 1 |
| Species | Homo sapiens (Human) |
| Biological_Activity | Measured by its binding ability in a functional ELISA. Immobilized OMA1 at 5 μg/ml can bind human BZW2, the EC50 of human BZM2 is 45.42-72.22 μg/ml. |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | HVFFRFNSLSNWRKCNTLASTSRGCHQVQVNHIVNKYQGLGVNQCDRWSFLPGNFHFYSTFNNKRTGGLSSTKSKEIWRITSKCTVWNDAFSRQLLIKEVTAVPSLSVLHPLSPASIRAIRNFHTSPRFQAAPVPLLLMILKPVQKLFAIIVGRGIRKWWQALPPNKKEVVKENIRKNKWKLFLGLSSFGLLFVVFYFTHLEVSPITGRSKLLLLGKEQFRLLSELEYEAWMEEFKNDMLTEKDARYLAVKEVLCHLIECNKDVPGISQINWVIHVVDSPIINAFVLPNGQMFVFTGFLNSVTDIHQLSFLLGHEIAHAVLGHAAEKAGMVHLLDFLGMIFLTMIWAICPRDSLALLCQWIQSKLQEYMFNRPYSRKLEAEADKIGLLLAAKACADIRASSVFWQQMEFVDSLHGQPKMPEWLSTHPSHGNRVEYLDRLIPQALKIREMCNCPPLSNPDPRLLFKLSTKHFLEESEKEDLNITKKQKMDTLPIQKQEQIPLTYIVEKRTGS |
| Research Area | Cell Biology |
| Source | in vitro E.coli expression system |
| Gene Names | OMA1 |
| Expression Region | 14-524aa |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Mol. Weight | 74.7kDa |
| Protein Description | Full Length of Mature Protein |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week. |
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| Function | Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. |
| Subcellular Location | Mitochondrion inner membrane, Multi-pass membrane protein |
| Protein Families | Peptidase M48 family |
| Tissue Specificity | Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver. |
| Database Links |
HGNC: 29661 KEGG: hsa:115209 STRING: 9606.ENSP00000360270 UniGene: Hs.425769 |
OMA1 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA016332GA01HU | OMA1 Antibody | Human,Mouse,Rat | ELISA,WB |
OMA1 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA856923LA01HU | OMA1 Antibody | Human | ELISA, WB, IHC, IF |
| CSB-PA856923LB01HU | OMA1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA856923LC01HU | OMA1 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA856923LD01HU | OMA1 Antibody, Biotin conjugated | Human | ELISA |
OMA1 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP856923HU1 CSB-EP856923HU1 CSB-BP856923HU1 CSB-MP856923HU1 |
Recombinant Human Metalloendopeptidase OMA1, mitochondrial(OMA1),partial | Yeast E.coli Baculovirus Mammalian cell |
Recombinant Mouse Integrin alpha-L(Itgal),partial
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Mouse Insulin-like growth factor-binding protein 1(Igfbp1)
Express system: E.coli
Species: Mus musculus (Mouse)
Recombinant Human High mobility group protein B1(Hmgb1)
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Intestinal-type alkaline phosphatase(ALPI)
Express system: Yeast
Species: Homo sapiens (Human)
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