| Code | CSB-PA856923LA01HU |
| Size |
US$299Purchase it in Cusabio online store (only available for customers from the US) |
| Image |
|
| The Latest Promotion |  |
| Have Questions? | Leave a Message or Start an on-line Chat |
| Full Product Name | Rabbit anti-Homo sapiens (Human) OMA1 Polyclonal antibody | ||||||||
| Uniprot No. | Q96E52 | ||||||||
| Target Names | OMA1 | ||||||||
| Alternative Names | OMA1; MPRP1; Metalloendopeptidase OMA1, mitochondrial; Metalloprotease-related protein 1; MPRP-1; Overlapping with the m-AAA protease 1 homolog | ||||||||
| Raised in | Rabbit | ||||||||
| Species Reactivity | Human | ||||||||
| Immunogen | Recombinant Human Metalloendopeptidase OMA1, mitochondrial protein (22-194AA) | ||||||||
| Immunogen Species | Homo sapiens (Human) | ||||||||
| Conjugate | Non-conjugated The OMA1 Antibody (Product code: CSB-PA856923LA01HU) is Non-conjugated. For OMA1 Antibody with conjugates, please check the following table. |
||||||||
| Clonality | Polyclonal | ||||||||
| Isotype | IgG | ||||||||
| Purification Method | >95%, Protein G purified | ||||||||
| Concentration | It differs from different batches. Please contact us to confirm it. | ||||||||
| Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
||||||||
| Form | Liquid | ||||||||
| Tested Applications | ELISA, WB, IHC, IF | ||||||||
| Recommended Dilution |
|
||||||||
| Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol |
||||||||
| Troubleshooting and FAQs | Antibody FAQs | ||||||||
| Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||||
| Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
There are currently no reviews for this product.
| Function |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX aggregation, mediates cleavage of OPA1, leading to the remodeling of mitochondrial cristae and allowing the release of cytochrome c from mitochondrial cristae. In depolarized mitochondria, may also act as a backup protease for PINK1 by mediating PINK1 cleavage and promoting its subsequent degradation by the proteasome. May also cleave UQCC3 in response to mitochondrial depolarization. Also acts as an activator of the integrated stress response (ISR): in response to mitochondrial stress, mediates cleavage of DELE1 to generate the processed form of DELE1 (S-DELE1), which translocates to the cytosol and activates EIF2AK1/HRI to trigger the ISR. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Binds cardiolipin, possibly regulating its protein turnover. Required for the stability of the respiratory supercomplexes.
|
| Gene References into Functions |
|
| Subcellular Location | Mitochondrion inner membrane; Single-pass membrane protein. |
| Protein Families | Peptidase M48 family |
| Tissue Specificity | Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver. |
| Database Links |
HGNC: 29661 KEGG: hsa:115209 STRING: 9606.ENSP00000360270 UniGene: Hs.425769 |
